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Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing GyrA S81F/ParC S79Y double mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method
Assay data:4 Tested
SummaryPubMed Citation
Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing GyrA S81Y/ParC S79F double mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method
Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing GyrA S81F/ParC S79F double mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method
Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing GyrB K143A/ParE T172A double mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method
Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing GyrB T172A/ParE T172A double mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method
Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing GyrB/ParE T172A mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method
Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing ParE/GyrB K143I mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method
Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing ParE/GyrB T172A mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method
Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing GyrA S81F/ParC S79Y double mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method wild type Streptococcus pneumoniae
Assay data:1 Tested
Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing GyrA S81Y/ParC S79F double mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method wild type Streptococcus pneumoniae
Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae D39 NCTC 7466 expressing GyrA S81F/ParC S79F double mutant assessed as growth inhibition after 18 to 24 hrs by CLSI broth microdilution method wild type Streptococcus pneumoniae
Antagonist activity at ComD1 receptor in Streptococcus pneumoniae D39 harboring pcomX/lacZ reporter gene assessed as inhibiton of CSP1-stimulated maximum signal preincubated for 30 mins followed by 50 nM CSP1 addition by ONPG based beta-galactosidase assay
Assay data:3 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Agonist activity at ComD1 receptor in Streptococcus pneumoniae D39 harboring pcomX/lacZ reporter gene incubated for 30 mins by ONPG based beta-galactosidase assay
Assay data:8 Active, 11 Activity ≤ 1 µM, 17 Tested
Inhibition of wild-type Streptococcus pneumoniae D39 ATP synthase atpE G145 mutant assessed as reduction in intracellular pH at >2 ug/ml measured at 5 mins by by pH-sensitive GFP-based fluorescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of wild-type Streptococcus pneumoniae D39 ATP synthase atpE G142C mutant assessed as reduction in intracellular pH at >0.25 to 8 ug/ml measured at 5 mins by by pH-sensitive GFP-based fluorescence assay
Inhibition of wild-type Streptococcus pneumoniae D39 ATP synthase atpE assessed as reduction in intracellular pH measured at 5 mins intervals by pH-sensitive GFP-based fluorescence assay
Antagonist activity at ComD1 receptor in Streptococcus pneumoniae D39 harboring pcomX/lacZ reporter gene assessed as inhibiton of CSP1-stimulated maximum signal at 10 uM preincubated for 30 mins followed by 50 nM CSP1 addition by ONPG based beta-galactosidase assay relative to native CSP1
Assay data:13 Tested
Inhibition of wild-type Streptococcus pneumoniae D39 ATP synthase atpE assessed as intracellular pH at 10 uM measured at 5 mins intervals by pH-sensitive GFP-based fluorescence assay (Rvb = 7.34 +/- 0.04 No_unit)
Inhibition of wild-type Streptococcus pneumoniae D39 ATP synthase atpE G142C mutant assessed as change in intracellular pH at 0.25 ug/ml measured at 5 mins by by pH-sensitive GFP-based fluorescence assay (Rvb = 7.34 +/- 0.04 No_unit)
Inhibition of wild-type Streptococcus pneumoniae D39 ATP synthase atpE assessed as intracellular pH at 0.25 ug/ml measured at 15 mins by pH-sensitive GFP-based fluorescence assay (Rvb = 7.34 +/- 0.04 No_unit)
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