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Binding affinity to C-terminal His10-tagged Escherichia coli B ER2560 SerRS expressed in Lemo21(DE3) SerRS assessed as affinity constant for second binding site by isothermal titration calorimetry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to C-terminal His10-tagged Escherichia coli B ER2560 SerRS expressed in Lemo21(DE3) SerRS assessed as affinity constant for first binding site by isothermal titration calorimetry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to C-terminal His10-tagged Escherichia coli B ER2560 SerRS expressed in Lemo21(DE3) SerRS assessed as dissociation constant by isothermal titration calorimetry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of C-terminal His10-tagged Escherichia coli B ER2560 SerRS expressed in Lemo21(DE3) using Ap4A as substrate in presence of serine by leuconostoc mesenteroides hexokinase/glucose 6-Phosphate dehydrogenase coupled UV-visible spectrophotometry
Assay data:6 Active, 2 Activity ≤ 1 µM, 9 Tested
Activity of Escherichia coli B lysyl-tRNA ligase after 15 mins by Lineweaver-Burk plot analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of Phe-tRNA synthetase in rel+ Escherichia coli B assessed as reduction of tRNA-Phe level after 30 mins
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of Phe-tRNA synthetase in rel+ Escherichia coli B assessed as growth inhibition
Assay data:5 Tested
Inhibition of rel+ Escherichia coli B Phe-tRNA synthetase using L-[3H]-phenylalanine as substrate by scintillation counting analysis
Assay data:4 Active, 3 Activity ≤ 1 µM, 5 Tested
Inhibition of ribosomal activity in Escherichia coli strain B assessed as inhibition of translation after 60 mins by coupled transcription/translation assay
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Binding affinity to C-terminal His10-tagged Escherichia coli B ER2560 SerRS expressed in Lemo21(DE3) SerRS assessed as binding stoichiometry at 2:1 ratio of compound to protein by isothermal titration calorimetry
Assay data:2 Active, 2 Tested
Inhibition of C-terminal His10-tagged Escherichia coli B ER2560 SerRS expressed in Lemo21(DE3) at 1 mM using Ap4A as substrate in presence of serine by leuconostoc mesenteroides hexokinase/glucose 6-Phosphate dehydrogenase coupled UV-visible spectrophotometry
SummaryPubMed CitationRelated BioAssays by Target
Non-competitive inhibition of Escherichia coli B thymidine kinase using [2-14C]-thymidine as substrate assessed as formation of [14C]-TMP at 16 mM after 10 mins by Lineweaver-Burk double reciprocal plot analysis
Inhibition of Phe-tRNA synthetase in rel+ Escherichia coli B assessed as growth inhibition at IC50 in presence of Pro
SummaryCompounds, ActivePubMed Citation
Inhibition of Phe-tRNA synthetase in rel+ Escherichia coli B assessed as growth inhibition at IC50 in presence of Ile
Inhibition of Phe-tRNA synthetase in rel+ Escherichia coli B assessed as growth inhibition at IC50 in presence of Tyr
Inhibition of Phe-tRNA synthetase in rel+ Escherichia coli B assessed as growth inhibition at IC50 in presence of Ser
Inhibition of Phe-tRNA synthetase in rel+ Escherichia coli B assessed as half maximal rate of [32P]ppGpp formation at 70 uM measured every 1 min by scintillation counting analysis
Inhibition of Phe-tRNA synthetase in rel+ Escherichia coli B assessed as [3H]-RNA synthesis at 92 uM after 5 mins by scintillation counting analysis in presence of [5-3H]-Uracil
Inhibition of Phe-tRNA synthetase in rel+ Escherichia coli B assessed as growth inhibition at 92 uM
Inhibition of Phe-tRNA synthetase in rel+ Escherichia coli B assessed as formation of [32P]ppGpp at 92 uM measured every 1 min by scintillation counting analysis
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