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Antibacterial activity against Legionella pneumophila Corby infected in differentiated human THP1 cells assessed as bacterial growth inhibition after 24 hrs
Assay data:2 Tested
SummaryPubMed Citation
Anti-infective activity against Legionella pneumophila harboring GFP in Acanthamoeba castellanii assessed as inhibition of bacterial replication at 30 uM by spectrophotometric method relative to vehicle control
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Antibacterial activity against Legionella pneumophila axenic forms harboring GFP at 30 uM by spectrophotometric method
Assay data:9 Active, 13 Tested
Antibacterial activity against Legionella pneumophila assessed as percent susceptible isolates by CLSI M7-A7 method
Assay data:7 Tested
Antibacterial activity against Legionella pneumophila by CLSI M7-A7 method
Antibacterial activity against Legionella pneumophila clinical isolate by broth microdilution method
Antibacterial activity against Legionella pneumophila
Assay data:5 Tested
Antibacterial activity against Legionella pneumophila after 24 hrs by broth microdilution method
Assay data:3 Tested
Antibacterial activity against Legionella pneumophila subsp. pneumophila
Assay data:18 Tested
Inhibition of Legionella pneumophila Mip assessed as reduction in PPIase activity using succinyl-Ala-Leu-Pro-Phe-4-nitroanilide as substrate incubated for 4 mins by absorbance method
Assay data:3 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of 5-(3-(4-(((5S,6S)-10-(3,5-dichlorophenylsulfonyl)-2-oxo-5-vinyl-3,10-diazabicyclo[4.3.1]decan-3-yl)methyl)-1H-1,2,3-triazol-1-yl)propylcarbamoyl)-2-(6-(dimethylamino)-3-(dimethyliminio)-3,10-dihydroanthracen-9-yl)benzoate from Legionella pneumophila Mip after 30 mins by fluorescence polarization assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Mip PPIase activity in Legionella pneumophila
Assay data:14 Active, 27 Tested
Inhibition of recombinant Legionella pneumophila 130b His6-tagged NTPDase (41 to 393 residues) expressed in Escherichia coli BL21(DE3) cells using ADP as substrate incubated for 10 mins by Cheng-Prusoff equation analysis
Inhibition of recombinant Legionella pneumophila 130b His6-tagged NTPDase (41 to 393 residues) expressed in Escherichia coli BL21(DE3) cells using ADP as substrate incubated for 10 mins by capillary electrophoresis method
Assay data:1 Active, 4 Tested
Binding affinity to Legionella pneumophila recombinant PAH by DSF assay
Assay data:1 Active, 1 Tested
Mixed inhibition of Legionella pneumophila recombinant PAH for enzyme-substrate complex by DSF assay method using L-Phe as substrate
Mixed inhibition of Legionella pneumophila recombinant PAH for free enzyme by DSF assay using L-Phe as substrate
Uncompetitive inhibition of Legionella pneumophila recombinant PAH for enzyme-substrate complex by DSF assay using L-Phe as substrate
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Uncompetitive inhibition of Legionella pneumophila recombinant PAH for free enzyme by DSF assay using L-Phe as substrate
Assay data:1 Tested
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