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Steady-State Kinetics from Article 10.1021/acs.biochem.5b01301: "Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase."
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Inhibition Kinetics from Article 10.1021/acs.biochem.5b01301: "Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase."
Assay data:20 Active, 9 Activity ≤ 1 µM, 22 Tested
FabZ Inhibition Assay from Article 10.1021/acs.biochem.5b00832: " -Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies."
Assay data:2 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Antimicrobial activity against Yersinia pseudotuberculosis YPIII PIB102-Elux at 364 uM by spectrophotometry
Assay data:3 Tested
SummaryPubMed Citation
Inhibition of YopH in Yersinia pseudotuberculosis YPIII PIB102-Elux using p-nitrophenyl phosphate as substrate measured after 3 hrs 15 mins by phosphatase enzyme assay
Assay data:3 Active, 4 Tested
Inhibition of YopE in Yersinia pseudotuberculosis YPIII PIB102-Elux measured after 3 hrs 15 mins by luminescent reporter-gene assay
Inhibition of YopH in Yersinia pseudotuberculosis YPIII expressing yopE-luxAB treated 3 hrs before substrate addition measured after 15 mins by microplate reader
Assay data:1 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antimicrobial activity against Yersinia pseudotuberculosis YPIII PIB102-Elux by spectrophotometry
Assay data:1 Tested
Inhibition of T3S in Yersinia pseudotuberculosis YPIII expressing yopE-luxAB at 200 uM after 3 hrs by luciferase reporter gene assay
Assay data:56 Tested
Inhibition of T3S in Yersinia pseudotuberculosis YPIII expressing yopE-luxAB at 100 uM after 3 hrs by luciferase reporter gene assay
Assay data:58 Tested
Inhibition of T3S in Yersinia pseudotuberculosis YPIII expressing yopE-luxAB at 50 uM after 3 hrs by luciferase reporter gene assay
Inhibition of T3S in Yersinia pseudotuberculosis YPIII expressing yopE-luxAB at 25 uM after 3 hrs by luciferase reporter gene assay
Inhibition of T3S in Yersinia pseudotuberculosis YPIII expressing yopE-luxAB at 12.5 uM after 3 hrs by luciferase reporter gene assay
Inhibition of T3S in Yersinia pseudotuberculosis YPIII expressing yopE-luxAB at 6.25 uM after 3 hrs by luciferase reporter gene assay
Inhibition of T3S in Yersinia pseudotuberculosis YPIII expressing yopE-luxAB at 3.13 uM after 3 hrs by luciferase reporter gene assay
Inhibition of T3S in Yersinia pseudotuberculosis YPIII expressing yopE-luxAB at 1.56 uM after 3 hrs by luciferase reporter gene assay
Inhibition of Yersinia pseudotuberculosis YP3 pIB1 LcrF-mediated cytotoxicity against mouse J774A1 cells assessed as LDH release at 50 ug/mL after 18 hrs by colorimetric assay
Assay data:6 Active, 8 Tested
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