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Inhibition of GlpG in Escherichia coli BL21 assessed as inhibition of FP-Rh labeling at 100 uM treated with compound prior to FP-Rh addition by competitive ABPP based analysis
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of GlpG in Escherichia coli BL21 assessed as inhibition of FP-Rh labeling at 200 uM treated with compound prior to FP-Rh addition by competitive ABPP based analysis
Assay data:2 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of GlpG in Escherichia coli BL21 assessed as inhibition of FP-Rh labeling treated with compound for 30 mins prior to FP-Rh addition by competitive ABPP based analysis
Assay data:1 Active, 6 Tested
Inhibition of CMY-2 in Escherichia coil BL21 assessed as inhibition of nitrocefin hydrolysis measured every 3 mins for 15 mins by UV spectrophotometer analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of Escherichia coli WecA incubated for 2 hrs using UDP-Glucosamine-C6-FITC substrate by by reversed-phase HPLC analysis
Assay data:4 Active, 3 Activity ≤ 1 µM, 11 Tested
Binding affinity to Escherichia coli BL21 (DE3) HPPK in presence of ATP and MgCl2 by fluorimetry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to Escherichia coli BL21 (DE3) HPPK incubated for 10 mins by fluorimetry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Binding affinity to Escherichia coli BL21 (lambda DE3) 2''-O-adenylyltransferase 1a by ATP-competitive inhibition assay
Assay data:3 Active, 7 Tested
Inhibition of Escherichia coli BL21 (lambda DE3) 2''-O-adenylyltransferase 1a by EnzChek pyrophosphate assay
Assay data:3 Active, 20 Tested
Inhibition of Escherichia coli MurA at 25 uM
Assay data:7 Active, 1 Activity ≤ 1 µM, 22 Tested
Inhibition of ribosomal activity in erythromycin-sensitive Escherichia coli BL21 S30 extracts assessed as inhibition of luciferase activity by transcriptional and translational assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of ribosomal activity in erythromycin-sensitive Escherichia coli BL21 assessed as luciferase production by transcriptional and translational assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [14C]ERY from erythromycin-sensitive Escherichia coli BL21 ribosome
Inhibition of IMP-1 in Escherichia coli BL21 assessed as reduction of imipenem MIC at 50 mM relative to control
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of IMP-1 in Escherichia coli BL21 assessed as imipenem MIC at 50 mM (Rvb = 2 ug/ml)
Inhibition of Escherichia coli MurA C115D mutant at 25 uM
Assay data:22 Tested
Inhibition of Escherichia coli MurA
Drug uptake in Escherichia coli BL21 AI assessed as intracellular localization at 30 ug/ml after 20 mins by confocal fluorescence microscopy
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Late stage assay provider counterscreen results from the probe development efforts to identify common IMP-1 and VIM-2 inhibitors: VIM-2-transformed E. coli growth inhibition dose response assay in the presence of imipenem
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
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