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Effect on german cockroach Nav1 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Assay data:1 Tested
SummaryPubMed Citation
Modulator activity at german cockroach Nav1 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-electrode voltage clamp assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Insecticidal activity against Blattella germanica (German cockroach) assessed as excitation at 10ug/cockroach applied topically after 24 hr
Assay data:5 Active, 9 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition of voltage-gated calcium channel Cav-mediated fast-transient current in Periplaneta americana (American cockroach) DUM neurons assessed as measured at holding potential -80 mV depolarized to +40 mV after 10 min by whole cell patch clamp assay in presence of CdCl2
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of voltage-gated calcium channel Cav-mediated late-sustained current in Periplaneta americana (American cockroach) DUM neurons assessed as measured at holding potential -80 mV depolarized to +40 mV after 10 min by whole cell patch clamp assay in presence of CdCl2
Inhibition of Blattella germanica peptidyl alpha-hydroxylating monooxygenase assessed as inhibition of N-dansyl-Tyr-Val-Gly amidation by RP-HPLC
Assay data:4 Active, 1 Activity ≤ 1 µM, 7 Tested
Inhibition of high voltage activated Cav channel in Periplaneta americana (American cockroach) DUM neurons assessed as effect on voltage-dependent activation at 330 nM measured at holding potential -90 mV depolarized to +70 mV with 10 mV increments after 10 min by whole cell patch clamp assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of mid-low voltage activated Cav channel in Periplaneta americana (American cockroach) DUM neurons assessed as effect on voltage-dependent activation at 330 nM measured at holding potential -90 mV depolarized to +70 mV with 10 mV increments after 10 min by whole cell patch clamp assay
Inhibition of voltage-gated calcium channel Cav-mediated fast-transient current in Periplaneta americana (American cockroach) DUM neurons assessed as effect on voltage-dependent activation at 6 nM measured at holding potential -80 mV in 10 mV increments depolarized to +40 mV after 10 min by whole cell patch clamp assay in presence of CdCl2
Inhibition of voltage-gated calcium channel Cav-mediated late-sustained current in Periplaneta americana (American cockroach) DUM neurons assessed as effect on voltage-dependent activation at 6 nM measured at holding potential -80 mV in 10 mV increments depolarized to +40 mV after 10 min by whole cell patch clamp assay in presence of CdCl2
Inhibition of voltage-gated calcium channel Cav-mediated fast-transient current in Periplaneta americana (American cockroach) DUM neurons assessed as effect on voltage-dependent activation at 25 nM measured at holding potential -80 mV in 10 mV increments depolarized to +40 mV after 10 min by whole cell patch clamp assay in presence of CdCl2
Assay data:2 Tested
Inhibition of voltage-gated calcium channel Cav-mediated late-sustained current in Periplaneta americana (American cockroach) DUM neurons assessed as effect on voltage-dependent activation at 25 nM measured at holding potential -80 mV in 10 mV increments depolarized to +40 mV after 10 min by whole cell patch clamp assay in presence of CdCl2
Ratio of LT50 for Blattella germanica Muncie fifth instars to LT50 for Blattella germanica Jwax fifth instars
Assay data:10 Tested
Ratio of LT50 for Blattella germanica Muncie second instars to LT50 for Blattella germanica Jwax second instars
Assay data:11 Tested
Ratio of compound KD50 to ryanodine KD50 for Blattella germanica (German cockroach) assessed as immobility
Inhibition of high voltage activated Cav channel in Periplaneta americana (American cockroach) DUM neurons assessed as reduction in barium current at 330 nM measured at holding potential -90 mV depolarized to +30 mV after 10 min by whole cell patch clamp assay relative to control
Inhibition of mid-low voltage activated Cav channel in Periplaneta americana (American cockroach) DUM neurons assessed as reduction in barium current at 330 nM measured at holding potential -90 mV depolarized to -20 mV after 10 min by whole cell patch clamp assay relative to control
Inhibition of Blattella germanica peptidylamidoglycolate lyase assessed as ascorbate-independent dealkylation of alpha-hydroxy-hipurate
Assay data:26 Tested
Insecticidal activity against insecticide-resistant Blattella germanica Muncie fifth instars
Insecticidal activity against insecticide-susceptible Blattella germanica Jwax fifth instars
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