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WecA Assay from US Patent US20240199677: "GLYCOSYLTRANSFERASE INHIBITORS"
Assay data:4 Active, 3 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Inhibition Assay from US Patent US11192850: "N-aryl oxamic acids"
Assay data:35 Active, 30 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Assay of Inhibition of Mycobacterium tuberculosis RNA Polymerase from US Patent US10800725: "Arylpropionyl-triketone antibacterial agents"
Assay data:17 Active, 8 Activity ≤ 1 µM, 20 Tested
CM Assay from Article 10.3109/14756366.2013.823958: "Identification and structure-activity relationship study of carvacrol derivatives as Mycobacterium tuberculosis chorismate mutase inhibitors."
Assay data:2 Active, 13 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
CA Inhibition Assay from Article 10.3109/14756366.2011.650168: "Inhibition of the -class carbonic anhydrases from Mycobacterium tuberculosis with carboxylic acids."
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
CA Inhibition Assay from Article 10.3109/14756366.2011.645539: "Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three -class carbonic anhydrases from Mycobacterium tuberculosis."
Assay data:11 Active, 7 Activity ≤ 1 µM, 11 Tested
Enzymatic Assay from US Patent US9394254: "Antibiotic and anti-parasitic agents that modulate class II fructose 1,6-bisphosphate aldolase"
Assay data:1 Active, 4 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
ICL Enzyme Assay from Article 10.3109/14756360903425221: "5-Nitro-2,6-dioxohexahydro-4-pyrimidinecarboxamides: synthesis, in vitro antimycobacterial activity, cytotoxicity, and isocitrate lyase inhibition studies."
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
3D-QSAR from Article 10.3109/14756360903049059: "3D-QSAR, molecular docking studies, and binding mode prediction of thiolactomycin analogs as mtFabH inhibitors."
Assay data:6 Active, 40 Tested
Isothermal Titration Calorimetry (ITC) from Article 10.1021/acschembio.7b00091: "Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays."
Assay data:1 Active, 8 Tested
Biolayer Interferometry (BLI) Assay from Article 10.1021/acs.biochem.6b01267: "Design, Synthesis, and Experimental Validation of Peptide Ligands Targeting Mycobacterium tuberculosis s Factors."
Assay data:3 Active, 3 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition Kinetics Assay from Article 10.1074/jbc.M113.511436: "Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis."
Assay data:1 Tested
Isothermal Titration Calorimetry (ITC) from Article 10.1074/jbc.M113.493767: "Structural basis of mycobacterial inhibition by cyclomarin A"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
MymA Inhibition Assay from Article 10.1111/cbdd.12840: "Characterization of MymA protein as a flavin-containing monooxygenase and as a target of isoniazid."
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Colorimetric Malachite Green Assay from Article 10.1021/acschembio.6b00510: "Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis."
Assay data:14 Tested
Biochemical Assay (ATP at 50x Km) from Article 10.1074/jbc.M113.476473: "Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase."
Assay data:4 Active, 2 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Biochemical Assay (ATP at Km) from Article 10.1074/jbc.M113.476473: "Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase."
Assay data:8 Active, 6 Activity ≤ 1 µM, 8 Tested
Inhibition Assay from US Patent US9073941: "Compounds and methods for treating tuberculosis infection"
Assay data:41 Active, 31 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:121 Active, 35 Activity ≤ 1 µM, 124 Tested
HPLC-based Assay from Article 10.1021/acschembio.5b00370: "Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents."
Assay data:4 Active, 16 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
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