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Inhibition of Lysine Gingipain from US Patent US10730826: "Ketone inhibitors of lysine gingipain"
Assay data:59 Active, 39 Activity ≤ 1 nM, 66 Activity ≤ 1 µM, 66 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of Lysine Gingipain from US Patent US10676470: "Inhibitors of lysine gingipain"
Assay data:33 Active, 1 Activity ≤ 1 nM, 34 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition Assay from US Patent US9988375: "Inhibitors of lysine gingipain"
Assay data:32 Active, 1 Activity ≤ 1 nM, 33 Activity ≤ 1 µM, 33 Tested
Antibacterial activity Porphyromonas gingivalis ATCC 33277 assessed as bacterial growth inhibition incubated for 24 hrs by broth dilution assay
Assay data:1 Tested
SummaryPubMed Citation
Antibacterial activity against Porphyromonas gingivalis ATCC 33277 by REMA
Assay data:2 Tested
Antibacterial activity against Porphyromonas gingivalis at 100 uM incubated for 5 days measured by WST-1 assay relative to control
Antibacterial activity against Porphyromonas gingivalis assessed as reduction of CFU at 10 uM incubated for 5 days measured by WST-1 assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Bactericidal activity against Porphyromonas gingivalis ATCC 33277 assessed as reduction in colony formation at 10 uM measured 24 hrs by safranin staining
Assay data:4 Tested
Antibiofilm activity against Porphyromonas gingivalis ATCC 33277 assessed as disruption of biofilm at 100 uM measured after 24 hrs by safranin staining
Assay data:6 Tested
Antibacterial activity against Porphyromonas gingivalis ATCC 33277 assessed as growth inhibition at 1 to 100 uM measured after 24 hrs by WST-1 assay relative to control
Antibiofilm activity against Porphyromonas gingivalis ATCC 33277 assessed as inhibition of biofilm at 10 uM measured after 48 hrs by safranin staining relative to control
Antibiofilm activity against Porphyromonas gingivalis ATCC 33277 assessed as inhibition of biofilm at 25 uM measured after 48 hrs by safranin staining relative to control
Antibiofilm activity against Porphyromonas gingivalis ATCC 33277 assessed as inhibition of biofilm at 50 uM measured after 48 hrs by safranin staining relative to control
Assay data:3 Tested
Antibiofilm activity against Porphyromonas gingivalis ATCC 33277 assessed as inhibition of biofilm at 100 uM measured after 48 hrs by safranin staining relative to control
Antibiofilm activity against Porphyromonas gingivalis ATCC 33277 assessed as inhibition of biofilm at 10 to 100 uM measured after 48 hrs by safranin staining relative to control
Bactericidal activity against Porphyromonas gingivalis ATCC 33277 assessed as reduction in colony formation at 10 uM measured 24 hrs by safranin staining relative to control
Assay data:3 Active, 6 Tested
Bactericidal activity against Porphyromonas gingivalis ATCC 33277 assessed as reduction in colony formation at 100 uM measured 24 hrs by safranin staining relative to control
Assay data:9 Tested
Antibacterial activity against Porphyromonas gingivalis ATCC 33277 assessed as growth inhibition at 100 uM measured after 30 mins by WST-1 assay relative to control
Assay data:7 Tested
Antibacterial activity against Porphyromonas gingivalis ATCC 33277 assessed as growth inhibition at 1 uM measured after 24 hrs by WST-1 assay relative to control
Antibacterial activity against Porphyromonas gingivalis ATCC 33277 assessed as growth inhibition at 50 uM measured after 24 hrs by WST-1 assay relative to control
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