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Agonist activity at human LXR-alpha expressed in CHO-K1 cells by PathHunter assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human LXR-alpha expressed in CHO-K1 cells assessed as maximum relative efficacy at 100 uM by PathHunter assay relative to TO901317
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Partial agonist activity against human LXRalpha in human HEK293T cells incubated for 24 hrs by reporter gene assay relative to T0901317
Agonist activity against human LXRalpha expressed in human HEK293T cells co-expressing CMX-GAL4N-hLXRalpha incubated for 24 hrs by reporter gene assay
Assay data:19 Active, 7 Activity ≤ 1 µM, 19 Tested
Agonist activity at human LXRalpha (187 to 447 residues) in Cos7 cells transfected with LBD-Gal4 and pGL435 Gal4 UAS Luc reporter plasmid at 10 uM by reporter gene assay
Agonist activity at human GAL4 DBD-fused LXRalpha LBD (182 to 447 residues) transfected in HEK293T cells assessed as fold activation at 10 uM incubated for 14 to 16 hrs by Renilla/Firefly dual-luciferase reporter assay
Binding affinity to full-length human LXRalpha by surface plasmon resonance assay
Assay data:3 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
ligand sensing assay (LiSA) from US Patent US10945978: "Treatment and diagnosis of melanoma"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
TBD from US Patent US10669296: "LXR agonists and uses thereof"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ligand sensing assay (LiSA) from US Patent US10543183: "Treatment and diagnosis of melanoma"
Radioligand Binding Assay from US Patent US9073931: "Liver X receptor modulators"
Assay data:33 Active, 25 Activity ≤ 1 µM, 43 Tested
Radioligand Binding Assay from US Patent US9006244: "Liver X receptor modulators"
Assay data:6 Active, 5 Activity ≤ 1 µM, 7 Tested
LXR Binding Assay and hLXR Reporter Assay from Article 10.1016/j.bmc.2008.12.048: "Biarylether amide quinolines as liver X receptor agonists."
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
LXRbeta Binding Assay (IC50) and LAFbeta Functional Assay (EC50) from Article 10.1016/j.bmc.2009.10.001: "4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists."
Assay data:16 Active, 17 Activity ≤ 1 µM, 17 Tested
Radioligand Binding Assay and Luciferase Transcriptional Reporter Gene Assay from Article 10.1016/j.bmcl.2009.01.109: "Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator."
Assay data:25 Active, 19 Activity ≤ 1 µM, 25 Tested
HTRF Cofactor Peptide Recruitment Assay from Article 10.1016/j.bmcl.2007.03.076: "Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists."
Assay data:44 Active, 30 Activity ≤ 1 µM, 63 Tested
HTRF Cofactor Peptide Recruitment Assay from Article 10.1016/j.bmcl.2007.06.017: "2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists."
Assay data:26 Active, 18 Activity ≤ 1 µM, 26 Tested
Fluorescence Resonance Energy Transfer (FRET) Ligand Sensing Assay (LiSA) from Article 10.1016/j.bmcl.2009.01.004: "Synthesis and SAR of potent LXR agonists containing an indole pharmacophore."
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
LXR Binding Assay and hLXR Reporter Assay from Article 10.1021/jm800799q: "Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride Synthesis"
Assay data:17 Active, 16 Activity ≤ 1 µM, 17 Tested
Reporter Gene Assay from Article 10.1016/j.bmc.2008.02.078: "Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development."
Assay data:6 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
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