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Protac activity at CRBN/IKZF1 in human KMS-11 cells assessed as induction of IKZF1 degradation at 5 uM pretreated with neddylation inhibitor MLN4924 for 2 hrs followed by compound addition and measured after 6 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Protac activity at CRBN/IKZF1 in human KMS-11 cells assessed as induction of IKZF1 degradation at 5 uM pretreated with proteosome inhibitor MLN9708 for 2 hrs followed by compound addition and measured after 6 hrs by Western blot analysis
Protac activity at CRBN/IKZF1 in human NCI-H929 cells assessed as induction of IKZF1 degradation at 2.5 uM incubated for 72 hrs by Western blot analysis
Assay data:2 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Protac activity at CRBN/IKZF1 in human KMS-11 cells assessed as induction of IKZF1 degradation at 2.5 uM incubated for 72 hrs by Western blot analysis
Induction of IKZF1 degradation in human KARPAS-299 cells assessed as reduction in IKZF1 expression at 1 uM measured after 24 hrs by Western blot analysis relative to control
Assay data:2 Tested
Induction of IKZF1 degradation in human GripTite 293 MSR cells assessed as reduction in IKZF1 level measured by PathHunter assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 177 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Protac activity at CRBN/IKZF1 in human MOLT-4 cells assessed as induction of IKZF1 degradation at 1 microM measured after 5 hrs by proteome mass spectrometry
Assay data:1 Active, 1 Tested
Induction of IKZF1 degradation in human CRBN-null MOLT4 cells at 8 to 200 nM incubated for 4 hrs by Immunoblotting analysis
Protac activity at CRBN/IKZF1 in human MOLT-4 cells assessed as induction of IKZF1 degradation at 250 microM measured after 4 hrs by proteome mass spectrometry
Protac activity at CRBN/IKZF1 in human MM1.S cells assessed as induction of IKZF1 degradation measured after 4 hrs by Immunoblotting analysis
Protac activity at CRBN/IKZF1 in human Jurkat cells assessed as induction of IKZF1 degradation measured after 4 hrs by Immunoblotting analysis
Protac activity at CRBN/IKZF1 in human MOLT-4 cells assessed as induction of IKZF1 degradation measured after 4 hrs by Immunoblotting analysis
Protac activity at CRBN/IKZF1 in human MOLT-4 cells assessed as induction of IKZF1 degradation at 1 microM measured after 4 hrs by Immunoblotting analysis
Assay data:3 Tested
Protac activity at CRBN/IKZF1 in human MOLT-4 cells assessed as induction of IKZF1 degradation at 200 nM measured after 4 hrs by Immunoblotting analysis
Prolabel Quantification of IKZF1, IKZF2, or GSPT1 Protein Levels in 293GT Cells from US Patent US11185537: "3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof"
Assay data:19 Active, 17 Activity ≤ 1 µM, 27 Tested
Protac activity at CRBN/IKZF1 in human MM1.S cells assessed as protein levels at 1 uM measured after 72 hrs by Western blot analysis relative to control
Assay data:4 Tested
Protac activity at CRBN/IKZF1 in human MM1.S cells assessed as protein levels at 1 uM measured after 6 hrs by Western blot analysis relative to control
Assay data:5 Tested
Protac activity at CRBN/IKZF3 in human MM1.S cells assessed as induction of IKZF3 degradation at 0.1 to 1 uM measured after 16 hrs by Western blotting analysis
Protac activity at CRBN/IKZF1 in human MM1.S cells assessed as induction of IKZF1 degradation at 1 uM incubated for 6 hrs relative to control
Assay data:25 Tested
Protac activity at CRBN/HiBiT-tagged IKZF1 in human MOLT-4 cells assessed as IKZF1 degradation by measuring luminescence by luminescence based HiBiT assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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