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MERTK, AXL, TYRO3 Kinase Homogeneous Time Resolved Fluorescence (HTRF) Assay from US Patent US20230339891: "URACIL DERIVATIVES AS MER-AXL INHIBITORS"
Assay data:128 Active, 13 Activity ≤ 1 nM, 128 Activity ≤ 1 µM, 128 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Human Mer Kinase Assay from US Patent US11708367: "Compounds for the treatment of kinase-dependent disorders"
Assay data:30 Active, 30 Activity ≤ 1 µM, 30 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Human Mer Kinase Assay from US Patent US11673897: "Compounds for the treatment of kinase-dependent disorders"
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
TAM Enzymatic Assay from US Patent US11591338: "Pyrrolotriazine compounds as TAM inhibitors"
Assay data:142 Active, 144 Activity ≤ 1 µM, 144 Tested
Mer Kinase Assay from US Patent US11542259: "Compounds for the treatment of kinase-dependent disorders"
Assay data:64 Active, 65 Activity ≤ 1 µM, 65 Tested
Selectivity interaction (Enzymatic assay) EUB0000624a MERTK
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (Upstate Kinase Profiler service (Millipore)) EUB0000056c MERTK
Affinity Biochemical interaction (HTRF assay) EUB0000147b MERTK
Affinity Phenotypic Cellular interaction (CellTiter-Glo assay (Promega, proliferation in H1703 cell line)) EUB0000147b MERTK
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Thermal Shift Assay. Domain: start/stop: E571-V864
Assay data:27 Tested
SummaryRelated BioAssays by Target
Inhibition of human wild type partial length Mer (R557 to L884 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by Kinomescan method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human wild type partial length Mer (R557 to L884 residues) expressed in bacterial expression system by Kinomescan method
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of MERTK (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary electrophoresis analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to MERTK (unknown origin)
Inhibition of human MER at 1 uM relative to control
Inhibition of Mer (unknown origin) at 1 uM
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to MERTK (unknown origin) assessed as dissociation constant by competition binding assay
MERTK DiscoveRx kinase panel
MERTK SGC Tm panel (DSF)
Mer(h) Kinase panel
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