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Microsomal stability in human liver microsomes assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM and measured for 15 mins in presence of UDPGA by UPLC-MS/MS analysis (Rvb = 100%)
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM measured immediately in presence of UDPGA by UPLC-MS analysis
Assay data:1 Tested
Drug metabolism in human liver S9 fractions assessed as assessed as UGT-mediated phase 2 metabolism at 1 mM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by RP-UHPLC-DAD analysis relative to control
Assay data:2 Tested
Drug metabolism in human liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 60 mins by UPLC-MS/MS analysis
Assay data:3 Tested
Drug metabolism in human liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 30 mins by UPLC-MS/MS analysis
Drug metabolism in human liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 15 mins by UPLC-MS/MS analysis
Drug metabolism assessed as human UGT-mediated metabolism by measuring intrinsic clearance
Drug metabolism assessed as human UGT-mediated metabolism by measuring half life for DHD3 formation
Drug metabolism assessed as human UGT-mediated metabolism by measuring half life for DHD1 formation
Microsomal stability in human liver microsomes assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM and measured for 60 mins in presence of UDPGA by UPLC-MS/MS analysis (Rvb = 100%)
Microsomal stability in human liver microsomes assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM and measured for 30 mins in presence of UDPGA by UPLC-MS/MS analysis (Rvb = 100%)
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM incubated for 15 mins in presence of UDPGA by UPLC-MS analysis
Drug metabolism in human hepatocytes assessed as UGT-mediated glucuronidation by measuring O-glucuronide formation at 10 uM measured after 4 hrs by LC-MS analysis
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
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