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In vitro ability to antagonize LTD4-induced contractions of guinea pig ileum.
Assay data:30 Tested
SummaryPubMed CitationRelated BioAssays by Target
In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).
Assay data:21 Active, 8 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Compound was evaluated for its antagonist affinity against LTD4 on human bronchial muscle
Assay data:2 Tested
SummaryRelated BioAssays by Target
Ability to antagonize LTD4 receptors isolated from guinea pig lung membranes
Assay data:9 Active, 2 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
Compound was tested for inhibitory activity against LTD4 (leukotriene).
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Compound was evaluated for the inhibition of serum-opsonized zymosan stimulated LTC4/D4 release from human neutrophil
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Compound was evaluated for the inhibition of anti-IgE stimulated LTC4/D4 release from human basophil
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of LTD4-induced contraction of guinea pig ileum; No data.
Assay data:22 Tested
Inhibition of LTD4-induced contraction of guinea pig ileum.
Assay data:10 Tested
In vitro inhibition of [3H]LTD4 binding to guinea pig lung membranes.
Assay data:15 Active, 12 Activity ≤ 1 µM, 18 Tested
Inhibitory activity of compound to block binding of radiolabeled Cysteinyl leukotriene D4 receptor sites in homogenized guinea pig lung at 10 uM
Assay data:1 Tested
In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).
Assay data:32 Active, 16 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
In vitro inhibition of leukotriene D4 induced contractions of isolated guinea pig ileum.
Assay data:18 Tested
Inhibition of LTC4-induced contraction of isolated guinea pig ileum.
Assay data:18 Active, 2 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
In vitro inhibition of SRS-A-induced contractions in guinea pig ileum
Assay data:18 Active, 16 Activity ≤ 1 µM, 18 Tested
Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileum
Assay data:80 Active, 12 Activity ≤ 1 nM, 67 Activity ≤ 1 µM, 83 Tested
In vivo inhibition of LTD4-induced bronchospasm in guinea pig at dose of 50 mg/kg
Assay data:31 Tested
Inhibition of the spasmogenic activity of LTD4 in guinea pig parenchymal strips.
Assay data:20 Active, 18 Activity ≤ 1 µM, 20 Tested
inhibition of the spasmogenic activity of LTD4 in guinea pig parenchymal strips at 10 uM.
Assay data:20 Tested
Dissociation constant on guinea pig tracheal spirals utilizing LTE4 as agonist
Assay data:26 Active, 15 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
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