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Selectivity interaction (Serine protease panel) EUB0000735a CTRC
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human pancreas chymotrypsin at 100 uM using Suc-Ala-Ala-Pro-Phe-AMC as substrate preincubated for 15 mins incubated followed by addition of substrate measured after 60 mins by measuring amount of AMC formed by spectrofluorimetric method
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human pancreas chymotrypsin using Suc-Ala-Ala-Pro-Phe-AMC as substrate preincubated for 15 mins incubated followed by addition of substrate measured after 60 mins by measuring amount of AMC formed by spectrofluorimetric method
Inhibition of human Chymotrypsin at 20 uM using Suc-Ala-Ala-Pro-Phe-NHMec as fluorogenic substrate preincubated for 15 mins followed by substrate addition by spectrophotometry analysis
Binding affinity to human chymotrypsin assessed as inhibition constant using 3-Carbomethoxypropionyl-L-arginyl-Lprolyl-L-tyrosine p-Nitroaniline as substrate measured upto 120 mins by spectrophotometric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Stability of the compound in PBS at pH 7.4 assessed as chymotrypsin (unknown origin)-mediated proteolysis by measuring remaining compound after 12 hrs by HPLC analysis
Assay data:2 Tested
Fluorescence Assay from Article 10.1021/cc700189b: "Diversity-oriented fluorescence library approach (DOFLA) to the discovery of chymotrypsin sensor."
Assay data:7 Tested
Enzyme Inhibition Assay from Article 10.1080/14756360701584653: "alpha-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn."
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human Neutrophil Elastase Inhibition Assay from Article 10.1021/jm070600+: "N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase."
Assay data:29 Active, 21 Activity ≤ 1 µM, 30 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1038/35422: "Design of potent selective zinc-mediated serine protease inhibitors."
Assay data:9 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 9 Tested
Chymotrypsin Assay from US Patent US9695194: "Benzoxazinone derivatives for treatment of skin diseases"
Assay data:12 Active, 11 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of Chymotrypsin (unknown origin) assessed as residual enzyme activity at 20 uM by FRET assay relative to control
Inhibition of chymotrypsin (unknown origin) at 10 uM relative to control
Inhibition of human chymotrypsin by spectrophotometry
Inhibition of mammalian chymotrypsin (unknown origin) using Suc-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins
Chymotrypsin inhibition percentage at 10 M by FRET kind of response from peptide substrate
Assay data:51 Tested
Inhibition of human chymotrypsin
Assay data:4 Tested
Inhibition of chymotrypsin (unknown origin) assessed as reduction in pNA release using chromogenic Suc-Ala-Ala-Pro-Phe-pNA substrate measured over 12.5 mins by spectrophotometry
Assay data:3 Tested
Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate at pH 8 and 298 K measured every 60 secs for 600 secs
Assay data:9 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 11 Tested
Substrate activity at chymotrypsin (unknown origin) by Michaelis-Menten plot analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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