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Antagonist activity at human alpha1beta1 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux
Assay data:4 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H]epibatidine from human alpha1/beta/gamma/delta nAchR expressed in TE-671 cell membrane
Assay data:1 Active, 1 Tested
Displacement of [3H]epibatidine from human alpha1betagammadelta nAchR expressed in TE-671 cell membrane at 5 uM
Assay data:15 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]-epibatidine from alpha1betagammadelta nAChR in human TE671 cellular membranes at 5 uM after 2 hrs by liquid scintillation counting
Displacement of [3H]-epibatidine from alpha1betagammadelta nAChR in human TE671 cellular membranes after 2 hrs by liquid scintillation counting
Late stage results from the probe development effort to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerization: Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late stage results from the probe development efforts to identify dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and nuclear factor NF-kappa-B (NF-kB): Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Binding affinity to human bungrotoxin binding site of nicotinic acetylcholine receptor alpha1 at 10 uM by radioligand binding assay
Assay data:1 Tested
Binding affinity to alpha1 nAchR expressed in human TE671 cells
Assay data:3 Active, 9 Tested
Agonist activity at human muscle-type alpha1beta1gammadelta nAChR in TE671/RD cells assessed as 86Rb+ efflux at 5 nM to 100 uM
Assay data:12 Tested
Antagonist activity against human muscle-type alpha1beta1gammadelta nAChR in TE671/RD cells assessed as inhibition of carbamylcholine induced 86Rb+ efflux
Assay data:6 Active, 13 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Late-stage counterscreen panel assay for S1P3 agonists: Ricerca HitProfilingScreen + CYP450
Late-stage counterscreen panel assay for GPR7 antagonists: Ricerca HitProfilingScreen + CYP450: Set 2
Late-stage counterscreen panel assay for S1P4 agonists: Ricerca HitProfilingScreen + CYP450: Set 2
Inactivation of nAChR alpha-1-beta-1-delta-gamma in human TE671/RD cells relative to carbamylcholine
Inactivation of nAChR alpha-1-beta-1-delta-gamma in human TE671/RD cells
Agonist activity at nAChR alpha-1-beta-1-delta-gamma in human TE671/RD cells assessed as induction in rubidium efflux relative to carbamylcholine
Agonist activity at nAChR alpha-1-beta-1-delta-gamma in human TE671/RD cells assessed as induction in rubidium efflux
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