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Inhibition of human ADCY8 assessed assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Ca2+/ CAM stimulated human AC8 expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation at 10 uM incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay relative to control
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Ca2+/ CAM stimulated human AC8 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay relative to control
Assay data:36 Tested
Inhibition of Ca2+/ CAM stimulated human AC8 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay
Assay data:25 Active, 7 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at recombinant human AC8 expressed in HEK293 cells assessed as increase in cAMP level at 50 uM measured after 30 mins by LANCE Ultra cAMP Detection kit method
Assay data:2 Active, 3 Tested
Agonist activity at recombinant human AC8 expressed in human HEK293 cells assessed as fold increase in cAMP level at 50 uM by LANCE Ultra cAMP Detection kit method relative to control
Assay data:2 Tested
Agonist activity at recombinant human AC8 expressed in human HEK293 cells assessed as fold increase in cAMP level by LANCE Ultra cAMP Detection kit method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation at 30 uM preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay relative to control
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay
Assay data:17 Active, 68 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Activation of adenylyl cyclase (unknown origin) at 10 uM
Inhibition of forskolin-stimulated adenylyl cyclase (unknown origin)
Inhibition of adenylyl cyclase (unknown origin)
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Inhibition of bPTH-stimulated adenylyl cyclase (unknown origin) activity at 500:1 compound to native hormone molar ratio
Agonist activity at adenylyl cyclase (unknown origin) at 1.35 x 10'-4 M
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
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