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Agonist activity at alpha3beta2 nAChR receptor by FLIPR assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human alpha4beta2 nAChR expressed in SH-EP1 cells assessed as 86Rb+ ion efflux after 9.5 mins by flip-plate technique
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at alpha4beta2 nAChR
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human alpha4beta2 nAChR expressed in HEK tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium accumulation after 1 hr by fluorescence assay
Assay data:2 Active, 4 Tested
Antagonist activity at human alpha4beta2 nAChR expressed in HEK tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium accumulation at 50 uM after 1 hr by fluorescence assay relative to control
Assay data:14 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
SummaryPubMed Citation
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Antagonist activity at human nAChR alpha4/beta2 receptor expressed in HEK ts201 cells assessed as calcium accumulation by fluorescence analysis
Assay data:42 Active, 75 Tested
Agonist activity at human recombinant alpha4beta2 nAChR in HEK293 cells by FLIPR assay
Assay data:2 Tested
Agonist activity at alpha4beta2 nAChR receptor by FLIPR assay
Agonist activity at human high sensitive and low sensitive alpha4beta2 nAChR expressed in SH-EP1 cells assessed as 86Rb+ ion efflux by flip-plate technique relative to sazetidine-A
Assay data:11 Tested
Displacement of [3H]epibatidine from human nAChR alpha4beta2 receptor expressed in human HEK293T cells by scintillation counting
Assay data:2 Active, 2 Activity ≤ 1 µM, 26 Tested
Binding affinity to human alpha4beta2 nAChR in HEK cells at 0.21 nM after 5 hrs by gamma counting in the presence of (+/-)-bupropion
Binding affinity to human alpha4beta2 nAChR in HEK cells at 78 nM after 2 hrs measured 10 mins post-irradiation by autoradiography in the presence of 160 uM (+/-)-bupropion
Negative allosteric modulation of human nAChR alpha4beta2 expressed in HEK ts201 cells assessed as decrease in epibatidine-induced calcium mobilization up to 100 uM measured every 1.5 sec by fluorescence analysis
Assay data:4 Tested
Negative allosteric modulation of human nAChR alpha4beta2 expressed in HEK ts201 cells assessed as inhibition of epibatidine-induced calcium mobilization at 0.1 to 100 uM measured every 1.5 sec by fluorescence analysis
Agonist activity at human nAChR alpha4beta2 expressed in HEK ts201 cells assessed as increase in calcium mobilization at 30 uM measured every 1.5 sec by fluorescence analysis
Assay data:21 Tested
Negative allosteric modulation of human nAChR alpha4beta2 expressed in HEK ts201 cells assessed as inhibition of epibatidine-induced calcium mobilization measured every 1.5 sec by fluorescence analysis
Assay data:6 Active, 17 Tested
Noncompetitive inhibition of human nAChR alpha4beta2 expressed in HEK ts201 cells assessed as inhibition of epibatidine-induced calcium mobilization at 30 uM measured every 1.5 sec by fluorescence analysis
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