BioAssay by Target (List) for Gene (Select 1143) - PubChem BioAssay - NCBI

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Select item 5173781.

Agonist activity at nAChR alpha3beta4 in human SHSY5Y cells assessed as induction in rubidium efflux

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 517378

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4597212.

Intrinsic activity at human alpha4beta4 nAChR receptor expressed in human SH-SY5Y cells assessed as 86Rb+ efflux at 5 to 100 uM by liquid scintillation counting

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-4; ...
Total:: 2

Assay data:34 Tested

AID:: 459721

Summary PubMed Citation Related BioAssays by Target

Select item 4607483.

Displacement of [3H]epibatidine from alpha3beta4 nAChR expressed in IMR32 cells

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 460748

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4650774.

Agonist activity at human alpha3beta4 nAChR in human IMR32 cells assessed as membrane depolarization after 1 hr by HPLC based fluorescence assay

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:2 Active, 2 Tested

AID:: 465077

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4650785.

Agonist activity at human alpha3beta4 nAChR in human SH-SY5Y cells assessed as membrane depolarization after 1 hr by HPLC based fluorescence assay

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:2 Active, 2 Tested

AID:: 465078

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4911756.

Agonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as induction of radiolabeled Rb+ influx at 0.005 to 100 uM by liquid scintillation counting

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-4; ...
Total:: 2

Assay data:23 Tested

AID:: 491175

Summary PubMed Citation Related BioAssays by Target

Select item 4911767.

Agonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as induction of radiolabeled Rb+ influx at 0.005 to 100 uM by liquid scintillation counting

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:23 Tested

AID:: 491176

Summary PubMed Citation Related BioAssays by Target

Select item 4911778.

Antagonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:16 Active, 26 Tested

AID:: 491177

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4911809.

Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-4; ...
Total:: 2

Assay data:1 Active, 26 Tested

AID:: 491180

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 49503310.

Displacement of [3H]epibatidine from alpha3beta4 nicotinic receptor expressed in human HEK293 cells

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:21 Active, 8 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested

AID:: 495033

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 49503611.

Agonist activity at alpha3beta4 nicotinic receptor expressed in human HEK cells assessed as intracellular calcium efflux by FLIPR

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:17 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 20 Tested

AID:: 495036

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 49503812.

Agonist activity at alpha3beta4 nicotinic receptor expressed in human HEK cells assessed as intracellular calcium efflux by FLIPR relative to control

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:18 Tested

AID:: 495038

Summary PubMed Citation Related BioAssays by Target

Select item 45971913.

Intrinsic activity at alpha3beta4 nAChR receptor in human SH-SY5Y cells assessed as 86Rb+ efflux at 5 to 100 uM by liquid scintillation counting

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:34 Tested

AID:: 459719

Summary PubMed Citation Related BioAssays by Target

Select item 51737914.

Agonist activity at nAChR alpha3beta4 in human SHSY5Y cells assessed as induction in rubidium efflux relative to carbamylcholine

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:1 Tested

AID:: 517379

Summary PubMed Citation Related BioAssays by Target

Select item 51738015.

Inactivation of nAChR alpha3beta4 in human SHSY5Y cells

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 517380

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 51738116.

Inactivation of nAChR alpha3beta4 in human SHSY5Y cells relative to carbamylcholine

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:1 Tested

AID:: 517381

Summary PubMed Citation Related BioAssays by Target

Select item 58930717.

Inhibition of alpha3beta4 nAChR

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 589307

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59168718.

Antagonist activity at human alpha3beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-3; ...
Total:: 2

Assay data:9 Active, 2 Activity ≤ 1 µM, 9 Tested

AID:: 591687

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59174319.

Antagonist activity at human alpha4beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-4; ...
Total:: 2

Assay data:3 Active, 9 Tested

AID:: 591743

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 61045420.

Antagonist activity against human alpha4beta4 nAChR in SHEP1 cells assessed as inhibition of carbamylcholine induced 86Rb+ efflux

Source:: ChEMBL

Protein Targets:: Neuronal acetylcholine receptor subunit alpha-4; ...
Total:: 2

Assay data:6 Active, 13 Tested

AID:: 610454

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (183)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (22)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (122)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (195)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (360)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (352)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (20)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 1143) (373)
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Model organism or animal sample from Mus musculus

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