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Displacement of ovine [125I-Tyr0]-CRF from mouse CRF1 receptor in pituitary gland at 20 mg/kg, po measured after 1 hr by gamma scintillation counter method relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of ovine [125I-Tyr0]-CRF from mouse CRF1 receptor in olfactory bulb at 20 mg/kg, po measured after 1 hr by gamma scintillation counter method relative to control
Displacement of ovine [125I-Tyr0]-CRF from mouse CRF1 receptor in frontal cortex at 20 mg/kg, po measured after 1 hr by gamma scintillation counter method relative to control
Antagonist activity at CRF-R1 in mouse AtT-20 cells assessed as inhibition of human CRF induced cAMP accumulation after 30 mins by radioimmunoassay
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
In vitro agonistic activity against mouse corticotropin releasing factor 1 receptor
Assay data:55 Tested
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor
Assay data:44 Active, 55 Activity ≤ 1 µM, 55 Tested
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