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Inhibition of MAPK14/P38-alpha (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of full length human wild type p38-alpha expressed in bacterial expression system assessed as residual activity at 1 uM relative to control
Binding affinity to P38-alpha (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of P38-alpha phosphorylation in human MEG01 cells at 0.01 to 3 uM after 1 hr by immunoblotting method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of P38-alpha phosphorylation in human KU812 cells at 0.01 to 3 uM after 1 hr by immunoblotting method
Inhibition of P38-alpha phosphorylation in human K562 cells at 0.01 to 3 uM after 1 hr by immunoblotting method
Inhibition of full length recombinant GST-tagged human p38-alpha expressed in Escherichia coli
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Increase in phosphorylated p38 level in human A549 cells at 10 to 50 uM after 24 hrs by Western blot analysis
Increase in phosphorylated p38 level in human HT-29 cells after 0.5 to 24 hrs by Western blot analysis
Increase in phosphorylated p38 level in human A549 cells after 0.5 hrs by Western blot analysis
Inhibition of full length recombinant human GST-tagged MAPK14 expressed in Escherichia coli at 1 uM by lantha screen kinase binding assay relative to control
Inhibition of full length recombinant human GST-tagged MAPK14 expressed in Escherichia coli at 5 uM by lantha screen kinase binding assay relative to control
Inhibition of N-terminal His6-tagged recombinant human SAPK2A T106M mutant expressed in baculovirus infected insect Sf9 cells assessed as remaining activity at 1 uM relative to control
Assay data:3 Tested
Inhibition of N-terminal His6-tagged recombinant human SAPK2A expressed in baculovirus infected insect Sf9 cells assessed as remaining activity at 1 uM relative to control
Inhibition of recombinant p38alpha MAP kinase (unknown origin) assessed as residual activity at 1 uM relative to control
Inhibition of human p38a MAPK (1 to 360 residues) at 1 uM by radioactive [33P]-ATP filter binding assay
Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addition measured after 1 hr by Z-LYTE assay
Assay data:30 Active, 1 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 30 Tested
Inhibition of human recombinant p38alpha assessed as residual activity at 10 uM after 1 hr by qPCR analysis relative to control
SummaryRelated BioAssays by Target
Inhibition of MAPK14 (unknown origin) at 10 uM
Inhibition of human MAPK14 at 10 uM
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