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Chaperone activity at wild type AGT (unknown origin) expressed in CHO cells co-expressing glycolate oxidase assessed as increase in protein level at 50 uM incubated for 7 days in presence of pyridoxine
Assay data:5 Tested
SummaryPubMed Citation
Chaperone activity at wild type AGT (unknown origin) expressed in CHO cells co-expressing glycolate oxidase assessed as increase in enzyme activity at 50 uM incubated for 7 days in presence of pyridoxine
Assay data:8 Active, 17 Tested
SummaryCompounds, ActivePubMed Citation
Chaperone activity at wild type AGT (unknown origin) expressed in CHO cells co-expressing glycolate oxidase assessed as increase in AGT protein level at 50 uM incubated for 7 days in presence of PLP by Western blot analysis
Assay data:3 Active, 12 Tested
Chaperone activity at wild type AGT (unknown origin) expressed in CHO cells co-expressing glycolate oxidase assessed as increase in enzyme activity at 50 uM using L-alanine and glyoxylate as a substrate preincubated for 7 days followed by substrate addition and measured after 10 to 60 mins in presence of PLP by spectrophotometric assay
Assay data:16 Tested
Inhibition of recombinant wild type His-tagged AGT (unknown origin) expressed in Escherichia coli BL21 assessed as dissociation rate constant using L-alanine and glyoxylate as a substrate in presence of PLP
Assay data:20 Tested
Inhibition of recombinant wild type His-tagged AGT (unknown origin) expressed in Escherichia coli BL21 assessed as association rate constant using L-alanine and glyoxylate as a substrate in presence of PLP
Inhibition of recombinant wild type His-tagged AGT (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using L-alanine and glyoxylate as a substrate in presence of PLP
Assay data:18 Active, 11 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of recombinant wild type His-tagged AGT (unknown origin) expressed in Escherichia coli BL21 using L-alanine and glyoxylate as a substrate in presence of PLP
Assay data:21 Active, 16 Activity ≤ 1 µM, 21 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
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A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
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Assay data:497 Active, 21019 Tested
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