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Inhibition of eIF4E in human Mino cells assessed as potentiation of ibrutinib induced antiproliferation at 100 uM preincubated for 48 hrs followed by thymidine addition measure after 16 hrs by Thymidine incorporation assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Binding affinity to eIF4E (unknown origin) by fluorescence quenching assay
Assay data:15 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of eIF4E-4E-BP1 (unknown origin) interaction at 100 uM by cat-ELCCA
Assay data:1 Tested
Inhibition of eIF4E (unknown origin)
Inhibition of eIF4E in human Z138 cells assessed as disruption of interaction between protein and mRNA 5'-cap at 10 to 100 uM by m7GTP pull-down assay
Inhibition of eIF4E in human GRANTA-519 cells assessed as disruption of interaction between protein and mRNA 5'-cap at 10 to 100 uM by m7GTP pull-down assay
Inhibition of eIF4E in human GRANTA-519 cells assessed as down regulation of c-Myc protein expression after 48 hrs by Western blot method
Inhibition of eIF4E in human Mino cells assessed as down regulation of c-Myc protein expression after 48 hrs by Western blot method
Inhibition of eIF4E in human GRANTA-519 cells assessed as increase in p27 protein expression after 48 hrs by Western blot method
Inhibition of eIF4E in human Mino cells assessed as increase in p27 protein expression after 48 hrs by Western blot method
Inhibition of eIF4E in human GRANTA-519 cells assessed as down regulation of Bcl-2 protein expression at 50 to 200 uM after 48 hrs by Western blot method
Inhibition of eIF4E in human Mino cells assessed as down regulation of Bcl-2 expression at 50 to 200 uM after 48 hrs by Western blot method
Inhibition of eIF4E in human Mino cells assessed as down regulation of c-Myc mRNA expression at 100 uM by RT-PCR based RNA Immunoprecipitation
Inhibition of eIF4E in human Mino cells assessed as potentiation of doxorobucin induced antiproliferation at 100 uM preincubated for 48 hrs followed by thymidine addition measure after 16 hrs by Thymidine incorporation assay
Inhibition of eIF4E in human Mino cells assessed as potentiation of dexamethasone induced antiproliferation at 100 uM preincubated for 48 hrs followed by thymidine addition measure after 16 hrs by Thymidine incorporation assay
Inhibition of eIF4E/eIF4G interaction in human CRL2813 cells assessed as increase in eIF4E/BP1 complex at 30 uM after 6 hrs by Western blotting analysis relative to control
Inhibition of eIF4E in human Mino cells assessed as down regulation of c-Myc protein expression at 10 to 25 uM after 48 hrs by Western blot analysis
Inhibition of eIF4E in human Mino cells assessed as down regulation of c-Myc protein expression at 100 uM after 48 hrs by Western blot analysis
Inhibition of eIF4E in human Mino cells assessed as down regulation of c-Myc protein expression at 100 uM after 48 hrs in presence of ibrutinib by Western blot analysis
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