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Inhibition of EGFR L851Q mutant (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
SummaryPubMed Citation
Human kinome siRNA screen in A549-BTR and MDA-231-1833-BTR cells
Assay data:49 Active, 714 Tested
Inhibition of human ERBB4 assessed as residual activity at 1 uM relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HER4 (unknown origin) at 10 uM after 30 mins relative to control
Assay data:1 Tested
Inhibition of human ErbB4 assessed as residual activity at 1 uM relative to control
Inhibition of EGFR T790M/L858M double mutant (unknown origin) expressed in baculovirus expression system using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA
Assay data:30 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 30 Tested
Inhibition of recombinant ErbB4 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of ErbB4 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assay
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
Binding affinity to ERBB4 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of HER4 (unknown origin) at 1 uM after 1 hr relative to control
Inhibition of human HER4 at 1 uM
Assay data:3 Active, 3 Tested
Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assay
Assay data:20 Active, 2 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 21 Tested
Competitive binding affinity to ERBB4 (unknown origin) at 10 uM in presence of ATP relative to control
Assay data:6 Tested
Inhibition of HER4 (unknown origin) at 10 uM relative to control
Inhibition of human EGFR extracellular domain/TIE2 intracellular domain transfected in mouse NIH/3T3 cells assessed as phosphotyrosine level preincubated for 60 mins followed by EGF stimulation by DELFIA assay
Assay data:10 Active, 2 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 11 Tested
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
Inhibition of HER4 (unknown origin) at 0.1 uM
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