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Kinase Assay from US Patent US20240109865: "INDAZOLE COMPOUNDS AS KINASE INHIBITORS"
Assay data:359 Active, 363 Activity ≤ 1 µM, 363 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of FGFR (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of FGFR4 in human Hep3B cells assessed as reduction in ERK phosphorylation by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of FGFR4 in human Hep3B cells assessed as reduction in AKT phosphorylation by Western blot analysis
Inhibition of FGFR4 phosphorylation in human Hep3B cells by Western blot analysis
Inhibition of recombinant His-tagged human FGFR4 (781 to 1338 residues) expressed in insect cells incubated for 1 hr by caliper mobility shift assay
Assay data:9 Active, 9 Activity ≤ 1 µM, 26 Tested
Inhibition of recombinant His-tagged human FGFR4 (781 to 1338 residues) expressed in insect cells at 1 uM incubated for 1 hr by caliper mobility shift assay relative to control
Assay data:26 Tested
Inhibition of FGFR4 (unknown origin) at 1 uM relative to control
Inhibition of recombinant human FGFR4 (460 to 802 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr in presence of ATP by HTRF assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human FGFR4
Inhibition of FGFR4 (unknown origin)
Inhibition of FGFR phosphorylation in human SNU-16 cells at 5 nM measured after 24 hrs
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of FGFR phosphorylation in human SNU-16 cells at 5 nM measured after 12 hrs
Inhibition of FGFR signalling in human SNU-16 assessed as inhibition of PLCgamma phosphorylation at 0.1 nM incubated for 2 hrs by Western blot analysis
Inhibition of FGFR signalling in human SNU-16 assessed as inhibition of pErk phosphorylation at 0.1 nM incubated for 2 hrs by Western blot analysis
Assay data:2 Active, 2 Tested
Inhibition of FGFR4 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysis
Inhibition of human recombinant FGFR4
Inhibition of human recombinant FGFR4 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysis
Inhibition of human recombinant FGFR4 in the presence of ATP at 0.8 uM measured after 1 hr by fluorescence based assay
Inhibition of FGFR4 (unknown origin) using biotin as substrate incubated for 1 hrs in the presence of ATP by HTRF assay
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