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Inhibition of SIK2 (unknown origin) at 1 uM relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
In Vitro SIK2 Kinase Assay from US Patent US20240025892: "SALT INDUCIBLE KINASE INHIBITORS"
Assay data:66 Active, 5 Activity ≤ 1 nM, 63 Activity ≤ 1 µM, 66 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of SIK; Abl and Src Kinases by Other Kinase Inhibitor from US Patent US20230348453: "HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF"
Assay data:29 Active, 29 Activity ≤ 1 µM, 29 Tested
SIK2 Kinase Activity Assay from US Patent US11725011: "Bicyclic urea kinase inhibitors and uses thereof"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000321b SIK2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Assay data:1 Tested
Inhibition of GST-tagged human SIK2 autophosphorylation at 5 nM measured after 30 mins in presence of [gamma33P]ATP by Western blot analysis
Inhibition of GST-tagged human SIK2 autophosphorylation measured after 30 mins in presence of [gamma33P]ATP by Western blot analysis
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human SIK2 by radiometric PanQinase activity assay
Inhibition of human SIK2 at 1 uM by radiometric PanQinase activity assay relative to control (Rvb=50%)
Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of tracer K10 by NanoBRET assay
Assay data:1 Active, 16 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of SIK2 (unknown origin) assessed as enzyme remaining activity by scanMAX kinase assay
Assay data:2 Active, 3 Tested
Inhibition of SIK2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of GST fused recombinant SIK2 (unknown origin) in human HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1 hr in presence of ATP by autoradiography based immunoblotting analysis
Assay data:1 Active, 1 Tested
Inhibition of GST fused recombinant SIK2 in HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser329 incubated for 1 hr in presence of ATP by autoradiography based immunoblotting analysis
SIK2 DiscoveRx kinase panel
SummaryRelated BioAssays by Target
SIK2(h) Kinase panel
Cellular target engagement assay with: SIK2
Inhibition of SIK2 (unknown origin) at 1 uM
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