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Binding affinity to recombinant human LARG (765 to 1138 residues) containing DH-PH catalytic module by microscale thermophoresis analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity to recombinant human LARG (765 to 1138 residues) V1099A mutant by microscale thermophoresis analysis
Binding affinity to recombinant human LARG (765 to 1138 residues) E982A mutant by microscale thermophoresis analysis
Binding affinity to recombinant human LARG (765 to 1138 residues) K979A mutant by microscale thermophoresis analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Binding affinity to recombinant human LARG (765 to 1138 residues) N983A mutant by microscale thermophoresis analysis
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human LARG (765 to 1138 residues) RhoGEF-catalyzed guanine nucleotide-exchange reaction of human full length RhoA (1 to 193 residues) by measuring inhibition of the GDP dissociation from RhoA by Alexa 647 fluorescence dye based GDP/GTP exchange assay
Inhibition of human LARG (765 to 1138 residues) RhoGEF binding to human full length RhoA (1 to 193 residues)
Assay data:2 Active, 2 Tested
Inhibition of human LARG (765 to 1138 residues) RhoGEF binding to human full length RhoA (1 to 193 residues) in presence of Rhosin/G04
Inhibition of human LARG (765 to 1138 residues) RhoGEF-catalyzed guanine nucleotide-exchange reaction of human full length RhoA (1 to 193 residues) by measuring inhibition of FL-GDP dissociation from RhoA by BODIPY-fluorescein(FL)-GDP nucleotide based assay
Inhibition of human LARG (765 to 1138 residues) RhoGEF-catalyzed guanine nucleotide-exchange reaction of human full length RhoA (1 to 193 residues) by measuring inhibition of TR-GTP association to RhoA by BODIPY-Texas Red(TR)-GTP nucleotide based assay
Inhibition of His6-tagged human LARG PH-DH domain expressed in mouse NIH/3T3 cells assessed as reduction in human full length GST-tagged RhoA (1 to 193 residues) interaction with LARG RhoGEF at 100 uM incubated for 1 hr by Western blot analysis relative to Y16
Assay data:5 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
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