Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Human FTase Assay from Article 10.3109/14756366.2011.643302: "New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis."
Assay data:5 Active, 1 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro PFT Activity Assay from Article 10.1016/j.chembiol.2009.01.014: "Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase."
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
FTase Scintillation Proximity Assay from Article : "Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro."
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In Vitro FTase/GGTase-1 Inhibition Assay from Article 10.1074/jbc.M600168200: "A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
In Vitro Enzyme Assay of FPT from Article 10.1021/jm980462b: "(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent."
Assay data:18 Active, 25 Activity ≤ 1 µM, 25 Tested
In Vitro FTase Inhibition Assay from Article 10.1021/jm010531d: "3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency."
Assay data:26 Active, 3 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 26 Tested
Enzyme Inhibition Assay from Article 10.1021/jm030434f: "Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors."
Assay data:45 Active, 20 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 45 Tested
Displacement of (1-(2-aminoethyl)-3,5-dimethyl-1H-pyrazol-4-yl)(4-((1-neopentyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)methanone from FNTA in vorinostat-stimulated human Jurkat 2C4 cells infected with latent HIV-1 by pull-down experiment based competitive binding assay
Displacement of (4-((1-neopentyl-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)(1,3,5-trimethyl-1H-pyrazol-4-yl)methanone from FNTA in vorinostat-stimulated human Jurkat 2C4 cells infected with latent HIV-1 by pull-down experiment based competitive binding assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of FTase in HEK293 cells assessed as reduction in H-ras farnesylation at 5 to 20 to 10 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis
SummaryRelated BioAssays by Target
Inhibition of FTase in HEK293 cells assessed as reduction in H-ras farnesylation at 5 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis
Inhibition of FTase in HEK293 cells assessed as reduction in H-ras farnesylation at 2.5 to 10 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis
Inhibition of human recombinant FTase using [3H]FPP as substrate after 15 mins by scintillation counting analysis
Inhibition of FTase in human PC3 cells assessed as reduction in HDJ2 farnesylation at 10 uM measured after 24 hrs by Western blot analysis
Assay data:2 Tested
Inhibition of FTase in human PC3 cells assessed as reduction in HDJ2 farnesylation at 1 uM measured after 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of FTase in human U937 cells assessed as reduction in p38 MAPK phosphorylation at 0.3 uM measured after 1 to 3 hrs y Western blot analysis
Inhibition of FTase (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 µM, 6 Tested
Inhibition of FTase (unknown origin) assessed as reduction in transfer of [3H]FPP to Ki-Ras
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of FTase (unknown origin) assessed as reduction in transfer of [3H]FPP to Ha-Ras
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of GGtase-1 in human RPMI8226 cells assessed as disruption of Rap1a geranylgeranylation after 48 hrs immunoblot analysis
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on