BioAssay by Target (List) for Gene (Select 2339) - PubChem BioAssay - NCBI

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Links from Gene

Items: 12

Select item 11404221.

Inhibition of recombinant GGTase 1 (unknown origin) assessed as decrease in prenylated fluorescent peptides level using dansyl-GCVLS and GGPP as substrate after 1 hr by HPLC-fluorescence detection analysis

Source:: ChEMBL

Protein Targets:: Geranylgeranyl transferase type-1 subunit beta; ...
Total:: 2

Assay data:5 Tested

AID:: 1140422

Summary PubMed Citation Related BioAssays by Target

Select item 7544932.

Inhibition of farnesyltransferase (unknown origin) assessed as KRAS farnesylation

Source:: ChEMBL

Protein Targets:: Protein farnesyltransferase subunit beta; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 754493

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2338183.

Relative selectivity farnesyl (Ha-ras-CVLS) and geranylgeranyl (Ha-ras-CVLL) transferases as ratio of IC50s

Source:: ChEMBL

Protein Targets:: Geranylgeranyl transferase type-1 subunit beta; ...
Total:: 3

Assay data:2 Tested

AID:: 233818

Summary PubMed Citation Related BioAssays by Target

Select item 1570564.

Minimal concentration required to inhibit Rap 1a processing (prenylation) in PSN-1 cell (not determined)

Source:: ChEMBL

Protein Targets:: Geranylgeranyl transferase type-1 subunit beta; ...
Total:: 2

Assay data:1 Tested

AID:: 157056

Summary PubMed Citation Related BioAssays by Target

Select item 747905.

Inhibition binding constant against Geranylgeranyl transferase type I

Source:: ChEMBL

Protein Targets:: Geranylgeranyl transferase type-1 subunit beta; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 74790

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 733946.

Inhibition of Farnesyltransferase

Source:: ChEMBL

Protein Targets:: Protein farnesyltransferase subunit beta; ...
Total:: 2

Assay data:2 Active, 2 Tested

AID:: 73394

Summary Compounds, Active Related BioAssays by Target

Select item 731217.

Compound ability to inhibit the transfer of [3H]- farnesyl from Farnesyltransferase to H-Ras-CVLS, a process that is mediated by FPT

Source:: ChEMBL

Protein Targets:: Protein farnesyltransferase subunit beta; ...
Total:: 2

Assay data:18 Active, 25 Activity ≤ 1 µM, 25 Tested

AID:: 73121

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 713268.

Inhibition of Farnesyltransferase

Source:: ChEMBL

Protein Targets:: Protein farnesyltransferase subunit beta; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 71326

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 713129.

In vitro inhibitory activity against farnesyltransferase (FT)

Source:: ChEMBL

Protein Targets:: Protein farnesyltransferase subunit beta; ...
Total:: 2

Assay data:44 Active, 25 Activity ≤ 1 nM, 44 Activity ≤ 1 µM, 44 Tested

AID:: 71312

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7130010.

Inhibitory activity against mammalian protein-farnesyltransferase

Source:: ChEMBL

Protein Targets:: Protein farnesyltransferase subunit beta; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 71300

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4667111.

Inhibiting the farnesylation of H-ras proteins in COS-7 monkey cells transiently expressing H-ras[Val12]-CVLS in the whole cell assay.

Source:: ChEMBL

Protein Targets:: Protein farnesyltransferase subunit beta; ...
Total:: 2

Assay data:19 Active, 19 Activity ≤ 1 µM, 22 Tested

AID:: 46671

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4665912.

In vitro inhibition of Ras processing by COS cells at 20 uM

Source:: ChEMBL

Protein Targets:: Protein farnesyltransferase subunit beta; ...
Total:: 2

Assay data:4 Tested

AID:: 46659

Summary PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (8)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (6)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (9)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (12)
BioAssays extracted from the literature

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BioAssay by Target (List) for Gene (Select 2339) (12)
PubChem BioAssay
Homo sapiens isolate:CHM13
Homo sapiens isolate:CHM13
Homo sapiens isolate:CHM13 RefSeq Genome sequencing and assembly

BioProject
BioProject Links for Nucleotide (Select 2462544359) (1)
BioProject
BioAssays, RNAi Target, Active for Gene (Select 2339) (0)
PubChem BioAssay
NT-3 growth factor receptor isoform X8 [Homo sapiens]
NT-3 growth factor receptor isoform X8 [Homo sapiens]
gi|2217301346|ref|XP_047288559.1|

Protein

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