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Inhibition of recombinant FLAG-tagged human dicer expressed in HEK293 cells assessed as reduction in pre-let-7g microRNA maturation at 5 to 10 uM after 40 mins by SYBR green2 dye based fluorescence assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity to dicer (unknown origin) assessed as inhibition of dicer-meditated pre-let-7d microRNA maturation at 100 uM by electrophoretic mobility shift assay
Assay data:2 Tested
Effect on Dicer (unknown origin) assessed as effect on 5'-gamma32P-ATP labeled pre-miRNA processing at 5 uM after 15 mins by gel electrophoresis assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Inhibition of human recombinant Dicer-mediated pre-miR-29a processing assessed as reduction of mature miR-29a formation at 200 uM after 3 hrs by Northern blot analysis
Assay data:2 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant Dicer-mediated long dsRNA digestion assessed as 21- to 23-mer short RNA formation at 200 uM after 3 hrs by denaturing-PAGE analysis
Assay data:6 Tested
Inhibition of human recombinant Dicer-mediated pre-miR-29a processing assessed as reduction of mature miR-29a formation by Northern blot analysis (Rvb = 41%)
Inhibition of human recombinant Dicer-mediated pre-miR-29a without internal loop processing assessed as reduction of mature miR-29a formation by Northern blot analysis (Rvb = 30%)
Inhibition of human recombinant Dicer-mediated pre-miR-29a without bulge loop processing assessed as reduction of mature miR-29a formation by Northern blot analysis (Rvb = 51%)
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
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