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In Vitro hDDAH-1 Assay from Article 10.3109/14756366.2011.573480: "Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase."
Assay data:1 Active, 13 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US9011882: "Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof"
Assay data:6 Active, 20 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
In Vitro HPLC Assay from US Patent US8921421: "Inhibitors of dimethylarginine dimethylaminohydrolase"
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition Assay from Article 10.1021/bi9007098: "Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide."
Assay data:6 Active, 2 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant DDAH1 reduction in L-citrulline formation using ADMA as substrate
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells at 1 mM using NMMA as substrate measured after 30 mins by colder reagent based microplate reader assay
Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells using NMMA as substrate measured after 30 mins by colder reagent based microplate reader assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 18 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human NG,NG-Dimethylarginine dimethylaminohydrolase 1 (Dimethylarginine dimethylaminohydrolases)
Assay data:1 Active, 1 Tested
Inhibition of DDAH in bronchial epithelial cells isolated from chronic obstructive pulmonary disease patient assessed as downregulation of TRPV1 gene expression at 5 to 50 uM after 24 hrs relative to vehicle-treated control
Inhibition of DDAH in bronchial epithelial cells isolated from chronic obstructive pulmonary disease patient assessed as downregulation of TNF-alpha gene expression at 5 to 50 uM after 24 hrs relative to vehicle-treated control
Inhibition of DDAH in fibroblasts isolated from chronic obstructive pulmonary disease patient assessed as upregulation of HO1 gene expression at 5 to 50 uM after 24 hrs relative to vehicle-treated control
Inhibition of DDAH in fibroblasts isolated from idiopathic pulmonary fibrosis patient assessed as downregulation of MMP8 gene expression at 5 to 50 uM relative to vehicle-treated control
Inhibition of DDAH in fibroblasts isolated from idiopathic pulmonary fibrosis patient assessed as downregulation of SMAD6 gene expression at 5 to 50 uM relative to vehicle-treated control
Inhibition of DDAH in fibroblasts isolated from idiopathic pulmonary fibrosis patient assessed as downregulation of BMPR2 gene expression at 5 to 50 uM relative to vehicle-treated control
Inhibition of DDAH in fibroblasts isolated from idiopathic pulmonary fibrosis patient assessed as downregulation of BMPR1B gene expression at 5 to 50 uM relative to vehicle-treated control
Inhibition of DDAH in fibroblasts isolated from idiopathic pulmonary fibrosis patient assessed as downregulation of MBP6 gene expression at 5 to 50 uM relative to vehicle-treated control
Inhibition of DDAH in fibroblasts isolated from idiopathic pulmonary fibrosis patient assessed as downregulation of BMP4 gene expression at 5 to 50 uM relative to vehicle-treated control
Inhibition of DDAH in fibroblasts isolated from idiopathic pulmonary fibrosis patient assessed as downregulation of BMP2 gene expression at 5 to 50 uM relative to vehicle-treated control
Inhibition of DDAH in fibroblasts isolated from idiopathic pulmonary fibrosis patient assessed as downregulation of TGFBR2 gene expression at 5 to 50 uM relative to vehicle-treated control
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