BioAssay by Target (List) for Gene (Select 23984) - PubChem BioAssay - NCBI

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Links from Gene

Items: 10

Select item 17868001.

Luciferase activity assay at 10 mikroM

Source:: ChEMBL

Protein Target:: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Assay data:1 Active, 1 Tested

AID:: 1786800

Summary Compounds, Active Related BioAssays by Target

Select item 17867992.

Luciferase activity assay at 1 mikroM

Source:: ChEMBL

Protein Target:: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Assay data:1 Active, 1 Tested

AID:: 1786799

Summary Compounds, Active Related BioAssays by Target

Select item 17867983.

SPA with mouse PDE10A

Source:: ChEMBL

Protein Target:: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1786798

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 12556994.

Inhibition of mouse PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 mins by scintillation proximity assay

Source:: ChEMBL

Protein Target:: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1255699

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12248285.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout

Source:: Iain Fraser

Assay data:762 Active, 16821 Tested

AID:: 1224828

Summary Related BioAssays by Same Project

Select item 12248266.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:1106 Active, 16821 Tested

AID:: 1224826

Summary Related BioAssays by Same Project

Select item 11816277.

Inhibition of mouse recombinant GST-tagged PDE10A using [3H]-cAMP as substrate after 30 mins by scintillation proximity assay

Source:: ChEMBL

Protein Target:: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1181627

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 10532088.

A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:788 Active, 16789 Tested

AID:: 1053208

Summary PubMed Citation

Select item 6773889.

Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting

Source:: ChEMBL

Protein Target:: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Assay data:48 Active, 3 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 49 Tested

AID:: 677388

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 60760310.

Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting

Source:: ChEMBL

Protein Target:: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Assay data:45 Active, 37 Activity ≤ 1 µM, 45 Tested

AID:: 607603

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (7)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (5)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (5)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (7)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (3)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (4)
BioAssays extracted from the literature
Other (6)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 23984) (10)
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