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Displacement of [125I]ET-1 from ET-A receptor in RASMC incubated for 60 mins
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cells
Assay data:6 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 7 Tested
Antagonist activity at rat aortic ring ETA receptor in presence of ET1
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Rat ETA receptor (Endothelin receptors)
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at endothelin A receptor in Wistar rat thoracic aorta strips assessed as inhibition of ET1-induced vasoconstriction preincubated for 5 mins followed by ET1 addition
Antagonist activity at endothelin A receptor in rat A7r5 cells assessed as inhibition of ET-1-induced increase in cytosolic free Ca2+ level treated 1 min prior to ET-1 addition by fura-2 dye-based spectrofluorometric analysis
Displacement of PD156707 from rat ETA receptor after 1 hr by Lowry method
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Antagonist activity at Sprague-Dawley rat ETA receptor assessed as inhibition of ET1-induced contraction of thoracic aortic ring at 10 uM after 30 mins
Assay data:17 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at ETA receptor in Sprague-Dawley Rattus norvegicus (rat) thoracic aortic ring assessed as inhibition of ET1-induced thoracic aortic ring contraction at 10 uM after 30 min relative to control
Assay data:15 Tested
SummaryRelated BioAssays by Target
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Antagonist activity at ETA receptor in Rattus norvegicus (rat) aorta assessed as inhibition of Kcl-induced contraction
Displacement of [125I]endothelin-1 from ETA receptor in rat A10 cells by scintillation counting
Assay data:3 Tested
Displacement of endothelin-1 from ETA receptor in rat A10 cells
Assay data:1 Active, 1 Tested
Endothelin pressor effect in rats after oral dose of 30 uM/kg
Assay data:7 Tested
In vivo prevention of ET-1-induced sudden death in rats by pretreatment with endothelin receptor antagonist at a dose of 10 mg/kg p.o.; Not determined
Assay data:1 Tested
In vivo prevention of ET-1-induced sudden death in rats by pretreatment with endothelin receptor antagonist at a dose of 30 mg/kg p.o.; nd = not determined
In vivo prevention of ET-1-induced sudden death in rats by pretreatment with endothelin receptor antagonist at a dose of 10 mg/kg p.o.; nd = not determined
In vivo prevention of ET-1-induced sudden death in rats by pretreatment with endothelin receptor antagonist at a dose of 100 mg/kg p.o.; nd = not determined
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