Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
In vivo antagonist activity at ERalpha in CRL:CD(SD) rat assessed as inhibition of estradiol-induced increase in uterine wet weight at 10 mg/kg, po administered as MCT suspension for 3 days and measured at 4 hrs post last dose on day 4
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H]-17beta-E2 from Sprague-Dawley rat uterine cytosol ER alpha after 3 hrs by Beckman scintillation counting method relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]-estradiol from rat uterine cytosolic estrogen receptor at 10'-10 to 10'-4 M by scintillation counting method relative to estradiol
Assay data:1 Tested
Rat Estrogen receptor-alpha (3A. Estrogen receptors)
Activation of ER-alpha/beta in rat H9c2 cells assessed as phosphorylated Akt level at 5,10 and 20 uM after 24 hrs by western blot analysis in presence of ER inhibitor ICI182780
Activation of ER-alpha/beta in rat H9c2 cells assessed as increase in phosphorylated Akt level after 24 hrs by western blot analysis
Effect on ER-mediated c-Jun protein level in Wistar rat at 10 uM in presence of ER antagonist ICI182/780 by Western blot analysis
Increase in ER-mediated c-Jun protein level in Wistar rat at 10 uM after 60 mins by Western blot analysis
Effect on ER-phosphorylation at Ser118 residue in Wistar rat hepatocytes nuclear extract at 10 uM after 30 to 120 mins pretreated with 1 uM ER antagonist ICI 182/780 for 30 mins before compound addition by Western blot analysis
Effect on ER-phosphorylation at Ser118 residue in Wistar rat hepatocytes nuclear extract at 10 uM after 60 to 120 mins by Western blot analysis
Increase in ER-phosphorylation at Ser118 residue in Wistar rat hepatocytes nuclear extract at 10 uM after 30 mins by Western blot analysis
Effect on ER-mediated Mrp3 mRNA level in Wistar rat hepatocytes at 10 uM after 5 hrs pretreated with 1 uM ER antagonist ICI 182/780 for 30 mins before compound addition by qRT-PCR analysis
Effect on ER-mediated Mrp3 mRNA level in Wistar rat hepatocytes at 10 uM after 5 hrs pretreated with 5 ug/ml RNA polymerase2 inhibitor actinomycin D for 30 mins before compound addition by qRT-PCR analysis
Effect on ER-mediated Mrp3 mRNA level in Wistar rat hepatocytes at 1 uM after 5 hrs by qRT-PCR analysis
Induction of ER-mediated Mrp3 mRNA level in Wistar rat hepatocytes at 10 uM after 5 hrs by qRT-PCR analysis
Antagonist activity at ER in rat GH3 cells assessed as inhibition of estradiol-induced prolactin gene expression at 10'-10 to 10'-6 M after 48 hrs by RT-PCR analysis
Assay data:9 Active, 9 Tested
Antagonist activity at ER in rat GH3 cells assessed as inhibition of estradiol-induced prolactin gene expression at 10'-6 M after 48 hrs by RT-PCR analysis
Assay data:3 Active, 3 Tested
Agonist activity at ER in rat GH3 cells assessed as increase in prolactin mRNA level at 10'-13 to 10'-6 M after 48 hrs by RT-PCR analysis relative to estradiol
Assay data:11 Tested
Agonist activity at ER in rat GH3 cells assessed as increase in prolactin mRNA level after 48 hrs by RT-PCR analysis
Displacement of radiolabeled estradiol from estradiol receptor in rat uterine cytosol
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on