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Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of sterol biosynthetic process gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as thermal stability by measuring melting temperature incubated overnight by fluorescence based assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of Shp mRNA expression at 10 uM measured after 24 hrs by RT-qPCR analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of Shp mRNA expression at 100 uM incubated for 24 hrs by RT-qPCR analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as upregulation of Cyp7a1 mRNA expression at 10 uM incubated for 24 hrs by RT-qPCR analysis
Assay data:2 Active, 2 Tested
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of Cyp7a1 mRNA expression at 100 uM incubated for 24 hrs by RT-qPCR analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of Shp mRNA expression at 10 uM incubated for 24 hrs by RT-qPCR analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of Cyp7a1 mRNA expression at 10 uM incubated for 24 hrs by RT-qPCR analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of cholestrol biosynthetic process gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis
Agonist activity at LRH-1 (unknown origin) transfected in human HeLa cells assessed as fold activation incubated for 24 hrs by DualGlo luciferase reporter gene assay
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of secondary alcohol biosynthetic process gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of alcohol biosynthetic process regulation gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of cholestrol biosynthetic process regulation gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of cholestrol metabolic process gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of cholestrol metabolic process regulation gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of steroid biosynthetic process regulation gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of lipid biosynthetic process gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis
Agonist activity at LRH-1 in human HepG2 cells assessed as downregulation of fatty-acyl-CoA biosynthetic process gene at 10 uM incubated for 24 hrs by RT-qPCR based RNA-seq analysis
Agonist activity at LRH1 LBD (unknown origin) assessed as reduction in NCOR2 recruitment by microarray assay
Ratio of binding affinity to human LRH1 LBD (291 to 541 residues) expressed in Escherichia coli by FRET assay to displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence polarization assay
Assay data:1 Tested
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