Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Rat NK2 receptor (Tachykinin receptors)
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H]substance P frome rat NK2 receptor
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of NKA-Bo binding to rat NK2 receptor expressed in HEK293 cells at 10 uM by FRET assay relative to neurokinin A
Assay data:30 Tested
SummaryPubMed CitationRelated BioAssays by Target
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as reduction of neurokinin A-induced cAMP production at 10 uM by radioimmunoassay
Assay data:2 Tested
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as enhancement of neurokinin A-induced intracellular calcium level at 20 uM by spectrofluorimetry
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as formation of active receptor cAMP-producing conformation at 50 uM in presence of 20nM NKA-Bo by FRET assay
Assay data:1 Tested
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as formation of active receptor cAMP-producing conformation at 10 uM in presence of 20nM NKA-Bo by FRET assay
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as formation of active receptor calcium-triggering conformation at 50 uM in presence of 20nM NKA-Bo by FRET assay
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as formation of active receptor calcium-triggering conformation at 10 uM in presence of 20nM NKA-Bo by FRET assay
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at NK2 receptor in rat urinary bladder assessed as effect on beta-Ala8]NKA(4-10)-induced mechanical activity
Assay data:40 Active, 40 Tested
Binding affinity against tachykinin receptor 2 from rat colon.
Assay data:28 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 28 Tested
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
Assay data:7 Active, 3 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
The compound was tested in vitro for antagonism against Tachykinin receptor 2 in rat colon muscularis mucosae.
SummaryRelated BioAssays by Target
Compound was evaluated for antagonism of contractile response of rat colon muscularis mucosae (RC) at tachykinin receptor 2; - indicates partial agonist Emax=60%
Assay data:1 Active, 1 Tested
Compound was evaluated for antagonism of contractile response of rat colon muscularis mucosae (RC) at tachykinin receptor 2
Assay data:24 Tested
Compound was evaluated for antagonism of contractile response of rat colon muscularis mucosae (RC) at Tachykinin receptor 2
Assay data:9 Tested
Antagonistic activity at tachykinin receptor 2 in the rat colon muscularis mucosae; C= Partial agonist
Antagonistic activity against the highly selective tachykinin receptor 2 in rat colon muscularis mucosae
Assay data:10 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on