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GABAA, Muscimol, Central Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
GABAA, Flunitrazepam, Central Eurofins Panlabs panel
GABAA, Chloride Channel, TBOB Eurofins Panlabs panel
BZD/CENTR/R Eurofins SafetyScreen44 (BI)
Displacement of [35S]-TBPS GABAA receptor in Wistar rat brain membrane incubated for 60 mins by competitive binding assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [35S]-TBPS from rat synaptosomes GABAA receptor incubated for 90 mins by liquid scintillation counting method
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of rat GABAA receptor
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
In vivo receptor occupancy at GABAA receptor in po dosed Sprague-Dawley rat assessed as plasma concentration causing 50% reduction at 0.39 mg/kg measured after 48 hrs by LC/MS method
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]diazepam from GABA-A receptor in rat brain membrane
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiseizure activity against pentylenetetrazole-induced clonic seizure in rat model assessed as inhibition of GABA-A receptor relative to control
Inhibition of GABAA benzodiazepine receptor in rat brain at 10 uM
Steroid Inhibition of TBPS Binding from US Patent US20230322846: "NEUROACTIVE STEROIDS AND THEIR METHODS OF USE"
Assay data:315 Active, 255 Activity ≤ 1 µM, 326 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Displacement of [3H]flunitrazepam from GABAA central benzodiazepine receptor in Wistar rat brain membrane without cerebellum measured after 60 mins by scintillation counting analysis relative to control
Assay data:2 Tested
Displacement of [3H]flunitrazepam from GABAA central benzodiazepine receptor in Wistar rat brain membrane without cerebellum measured after 60 mins by scintillation counting analysis
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