Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of GABA-A benzodiazepine receptor alpha-2-beta-3-gamma-2 subunits at 1 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]Ro-151788 from human GABA-A receptor alpha-2-beta-3-gamma-2 subunits expressed in L(tk-) cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human gamma-amino butyric-acid A receptor alpha-2-beta-3-gamma-2, using a [3H]-Ro- 15-1788 radioligand
Assay data:23 Active, 31 Activity ≤ 1 µM, 31 Tested
Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha-2-beta-3-gamma-2 subunits
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Maximal response relative to Gamma-aminobutyric acid A against human Gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytes
Assay data:8 Tested
Maximum modulation relative to GABA EC20 against human GABA-A receptor alpha-2-beta-3-gamma-2 subunits expressed in mammalian fibroblast L(tk-) cells
Assay data:2 Tested
Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunits
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Maximal potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunits
Assay data:3 Tested
Binding affinity measured using LtK- cell membranes expressing GABA alpha-2-beta-3-gamma-2 receptor
Assay data:21 Active, 23 Activity ≤ 1 µM, 30 Tested
Binding affinity for GABA-A alpha-2-beta-3-gamma-2 receptor expressed in L(tk-) cells
Binding affinity tested against alpha-2-beta-3-gamma-2 GABAA/BzR receptor subtype.
Assay data:38 Active, 1 Activity ≤ 1 nM, 43 Activity ≤ 1 µM, 49 Tested
Binding affinity against alpha-2-beta-3-gamma-2 GABA-A benzodiazepine receptor subunits (data unavailable)
Assay data:6 Tested
Displacement of [3H]Ro-151788 from human GABA-A receptor alpha-2-beta-3-gamma-2 subunits expressed in L(tk-) cells (<50% inhibition at 2 uM)
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity for alpha-2-beta-3-gamma-2 GABA-A benzodiazepine receptor subunits
Direct channel-gating action blocked by picrotoxin
GABA ratio, relative binding in the presence and absence of 10 uM GABA (IC50-GABA/IC50+GABA)
Assay data:13 Tested
Displacement of [3H]flumazenil from bovine benzodiazepine receptor GABA-A channel of brain membranes
Assay data:14 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 16 Tested
Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 subtype expressed in L (tk-) cells
Assay data:88 Active, 100 Activity ≤ 1 µM, 100 Tested
Displacement of [3H]-Ro- 15-1788 from human gamma-aminobutyric-acid GABA-A receptor alpha-2-beta-3-gamma-2 expressed in L(tk-) cells
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on