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Inhibition of Gamma-aminobutyric acid receptor
Assay data:3 Tested
SummaryRelated BioAssays by Target
Binding affinity for GABA-A benzodiazepine receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]muscimol from Gamma-aminobutyric acid A (GABA-A) receptor
Displacement of [3H]GABA from gamma-aminobutyric-acid A (GABA-A) receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Binding affinity in vivo for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]-GABA agonist from rat brain preparations after iv injection.
Assay data:20 Active, 13 Activity ≤ 1 µM, 23 Tested
Affinity for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]gabazine antagonist from rat brain preparations.
Assay data:12 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 12 Tested
Percentage of GABA-induced chloride currents, compound with 10E-4 M 4-biphenylacetic acid
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Percentage of GABA-induced chloride currents with compound alone at 10 e-4 M
Assay data:12 Tested
Percentage of GABA-induced chloride currents with 10e-4 M 4-biphenylacetic acid
Assay data:9 Tested
Percentage of GABA-induced chloride currents with 10 e-5 M 4-biphenylacetic acid
Inhibition of [35S]t-butyl-phosphorothionate (TBPS) binding to Gamma-aminobutyric acid receptor
Assay data:12 Active, 5 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity against recombinant Gamma-aminobutyric acid A (GABA-A) receptor
Binding of [3H]- TBPS radioligand against Gamma-aminobutyric acid receptor at 100 uM
Assay data:5 Tested
Inhibition of [3H]muscimol binding to GABA-A receptor at 100 uM
In vitro binding affinity for neuronal GABA-A receptor
Assay data:4 Tested
Binding of [3H]- muscimol radioligand against GABA receptor/chloride channel complex at 100 uM
Assay data:7 Tested
Binding of [3H]- Diazepam radioligand against GABA receptor/chloride channel complex at 100 uM
Inhibition of [3H]TBPS binding to GABA-A receptor at 100 uM
Assay data:2 Tested
Displacement of [3H]gamma-amino butyric acid from Gamma-aminobutyric acid (GABA-A) receptor of human cerebellar cortex preparation
Assay data:3 Active, 3 Activity ≤ 1 µM, 6 Tested
In vitro inhibition of [3H]muscimol binding to Gamma-aminobutyric acid receptor of human astrocytes
Assay data:5 Active, 1 Activity ≤ 1 µM, 6 Tested
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