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Inhibition of recombinant human GST-tagged GCN5 expressed in bacterial system using histone H3 as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by radiometric gel assay in presence of [3H]acetyl-CoA
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
Competitive inhibition of recombinant full-length human PCAF catalytic domain/GCN5 expressed in Escherichia coli BL21(DE3) using [14C]-acetyl CoA as substrate after 1 to 10 mins by double reciprocal plot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human GCN5
SummaryRelated BioAssays by Target
Inhibition of human GCN5 by BROMOscan assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant GCN5 (unknown origin)
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Binding affinity to KAT2A in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assay
Assay data:3 Tested
Inhibition of recombinant human KAT2A using biotinylated histone H3 (1 to 21 amino acid residues) as substrate at 50 uM preincubated for 10 mins followed by acetyl-CoA addition measured after 10 mins by time resolved fluorescence assay
Assay data:28 Tested
Inhibition of recombinant human KAT2A using biotinylated histone H3 (1 to 21 amino acid residues) as substrate preincubated for 10 mins followed by acetyl-CoA addition measured after 10 mins by time resolved fluorescence assay
Assay data:9 Active, 21 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Binding affinity to biotinylated GCN5L2 (unknown origin) expressed in Escherichia coli at 0.2 to 1 uM by Biolayer Interferometric analysis
Assay data:2 Tested
Inhibition of recombinant human GCN5L2 expressed in bacterial system assessed as residual activity at 1 uM by bromoscan assay relative to control
Inhibition of recombinant human GCN5 catalytic domain (497 to 663 residues) expressed in Escherichia coli using histone H3 (5 to 23 residues) as substrate at 800 uM after 1 hr by liquid scintillation counting method in presence of [3H]acetyl-CoA relative to control
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
Inhibition of GCN5 (unknown origin) using N-terminal histone H3 substrate by radiometric filter binding based phenotypic screen in presence of [3H]acetyl-CoA
Displacement of biotinylated ligand from recombinant His-tagged GCN5 long isoform (unknown origin) measured after 10 mins by TR-FRET assay
Binding affinity to human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOScan assay
Inhibition of GCN5 in human MV4-11 cells assessed as reduction of acetylated H3K14 level up to 100 uM after 24 hrs by Western blot analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of GCN5 (unknown origin)
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