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Inhibition of human recombinant myostatin pre-incubated with compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene assay
Assay data:2 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells after 4 hrs by dual-luciferase reporter gene assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 1 uM after 4 hrs by dual-luciferase reporter gene assay
Assay data:12 Active, 12 Tested
Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 3 uM after 4 hrs by dual-luciferase reporter gene assay
Assay data:3 Active, 16 Tested
Inhibition of human recombinant myostatin expressed in HEK293 cells after 4 hrs by SBE4 based luciferase reporter gene assay
Assay data:1 Active, 1 Tested
Inhibition of human recombinant myostatin expressed in HEK293 cells at 3 uM after 4 hrs by SBE4 based luciferase reporter gene assay
Assay data:3 Active, 3 Tested
Inhibition of human recombinant myostatin expressed in HEK293 cells at 10 uM after 4 hrs by SBE4 based luciferase reporter gene assay
Assay data:18 Active, 29 Tested
Inhibition of interaction of myostatin (unknown origin)/ActRIIA-ECD complex with ALK4-ECD-Fc at 25 uM after 120 secs by competitive binding/ Blitz binding assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Binding affinity to recombinant myostatin (unknown origin) by surface plasmon resonance assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of human recombinant myostatin pre-incubated with 30 uM compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene assay
Assay data:2 Active, 10 Tested
Inhibition of human recombinant myostatin pre-incubated with 30 uM compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated Smad2 phosphorylation by Western blotting method
Assay data:1 Active, 5 Tested
Inhibition of human recombinant myostatin pre-incubated with 5 uM compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated Smad2 phosphorylation by Western blotting method
Inhibition of recombinant myostatin (unknown origin) expressed in HEK293 cells at 5 uM after 4 hrs by dual-luciferase reporter gene assay relative to control
Assay data:2 Tested
Inhibition of human recombinant myostatin pre-incubated with 5 uM compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene assay
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
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