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Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor ionotropic kainate 6 (GluR6) expressed in Sf 9 insect cells
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]kainate as radioligand; value according to table 4
Assay data:1 Tested
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]kainate as radioligand; value given as 15406, 12040 according to table 4
Binding affinity against human GluR6
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]kainate as radioligand
Whole-cell voltage clamp recordings made from HEK293 cells stably transfected with human Ionotropic glutamate receptor ionotropic GluR6.Results are expressed as % of maximum inward current evoked
Whole-cell voltage clamp recordings made from HEK293 cells stably transfected with human Ionotropic glutamate receptor ionotropic kainate 2.Results are expressed as % of maximum inward current evoked; Nd is Not Determined.
Whole-cell voltage clamp recordings made from HEK293 cells stably transfected with human Ionotropic glutamate receptor ionotropic kainate 2.Results are expressed as % of maximum inward current evoked
Assay data:4 Tested
Electrophysiological activity at 1 uM domoate from HEK293 cells transfected with ionotropic glutamate receptor kainate 2
Assay data:34 Tested
Electrophysiological activity at 10 uM domoate from HEK293 cells transfected with Ionotropic glutamate receptor kainate 2
Electrophysiological activity at 30 uM domoate from HEK293 cells transfected with ionotropic glutamate receptor kainate 2
Ability to displace binding of [3H]AMPA to recombinant human AMPA receptor Ionotropic glutamate receptor ionotropic kainate 2
Ability to displace binding of [3H]KA to recombinant human KA receptor Ionotropic glutamate receptor ionotropic kainate 2 expressed in EK 293 cell membranes
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]kainate as radioligand
Assay data:29 Active, 9 Activity ≤ 1 µM, 42 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Compound has been evaluated for its binding affinity towards kainate by displacing the radioligand [3H]kainate
Inhibition of binding of [3H]kainate to kainate at 10 uM compound concentration
Ability to displace [3H]kainate from kainate receptor
Assay data:9 Active, 3 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
The compound was tested for binding affinity against Kainate binding site using [3H]kainate as radioligand
Assay data:8 Active, 1 Activity ≤ 1 µM, 8 Tested
The compound was tested for binding affinity against Kainate binding site using [3H]kainate as radioligand.
SummaryCompounds, ActiveRelated BioAssays by Target
The compound was tested for binding affinity against Kainate binding site using [3H]kainate as radioligand; Not tested
SummaryRelated BioAssays by Target
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