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Antagonist activity at NMDA receptor (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) stably expressed in HEK293 cells assessed as ratio of Fmax/F0 fluorescence curve value
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) stably expressed in HEK293 cells assessed as glutamate/glycine induced increase in intracellular calcium level at 10 uM incubated for 30 mins followed by addition of glutamate/glycine by Ca2+ influx assay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H]ifenprodyl from NMDA receptor (unknown origin)
Displacement of [3H]MDL from NMDA receptor (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Positive allosteric modulator activity at GluN2A NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a assessed as maximum potentiation at 30 uM in the presence of L-glutamate and glycine by Ca2+ influx assay relative to control
Assay data:18 Tested
Positive allosteric modulator activity at GluN2A NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glutamate and glycine by Ca2+ influx assay
Assay data:10 Active, 3 Activity ≤ 1 µM, 18 Tested
Inhibition of NMDA receptor (unknown origin) at 10 uM
Assay data:1 Tested
NR2B Radioligand Binding Assay from US Patent US11752155: "Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders"
Assay data:11 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Whole-Cell Patch Clamp from US Patent US11613556: "Oxysterols and methods of use thereof"
Assay data:4 Active, 36 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity to TCP-stimulated NMDA (unknown origin)
Assay data:1 Active, 1 Tested
Binding affinity to NMDA receptor (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human GluN1/N2A expressed in HEK293 cells assessed as NMDA/glycine-induced fraction of total transmembrane voltage field at 10 uM preincubated for 20 secs followed by NMDA treatment for 10 secs by patch-clamp method
Inhibition of GluN1/N2A (unknown origin) expressed in human tsA201 cells assessed as glutamate-induced change in voltage at -65 mV holding potential for 30 secs by whole-cell patch-clamp method
Binding affinity to NMDAR (unknown origin) assessed as inhibition constant by [3H]MK-801 binding assay
Positive allosteric modulator activity at GluN1a/GluN2A (unknown origin) expressed in CHO cells assessed as maximum potentiation at 30 uM in presence of glutamate by Ca2+ influx assay relative to control
Assay data:16 Tested
Positive allosteric modulator activity at GluN1a/GluN2A (unknown origin) expressed in CHO cells in presence of glutamate by Ca2+ influx assay
Assay data:10 Active, 5 Activity ≤ 1 µM, 13 Tested
Positive allosteric modulator activity at GluN2A receptor (unknown origin) assessed as maximum potentiation by FLIPR assay relative to control
Assay data:3 Tested
Positive allosteric modulator activity at GluN2A receptor (unknown origin) by FLIPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method relative to control
Assay data:17 Tested
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