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Antagonist activity at NMDA receptor (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]ifenprodyl from NMDA receptor (unknown origin)
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]MDL from NMDA receptor (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Positive allosteric modulator activity at GluN2D NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a assessed as maximum potentiation at 30 uM in the presence of L-glutamate and glycine by Ca2+ influx assay
Assay data:1 Tested
Positive allosteric modulator activity at GluN2D NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glutamate and glycine by Ca2+ influx assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of NMDA receptor (unknown origin) at 10 uM
Binding affinity to TCP-stimulated NMDA (unknown origin)
Binding affinity to NMDA receptor (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to NMDAR (unknown origin) assessed as inhibition constant by [3H]MK-801 binding assay
Positive allosteric modulator activity at GluN1a/GluN2D (unknown origin) expressed in CHO cells at 30 uM in presence of glutamate by Ca2+ influx assay relative to control
Positive allosteric modulator activity at GluN1a/GluN2D (unknown origin) expressed in CHO cells in presence of glutamate by Ca2+ influx assay
Positive allosteric modulation of recombinant human GluN1/GluN2D receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method relative to control
Positive allosteric modulation of recombinant human GluN1/GluN2D receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method
Inhibition of NMDA receptor (unknown origin) at 50 uM by radioligand receptor binding assay relative to control
Antagonist activity at GluN1/GluN2D NMDA receptor (unknown origin) transfected in HEK293 cells assessed as inhibition of glycine induced current response at 10 uM in presence of L-glutamate by patch-clamp method
Inhibition of NMDA receptor (unknown origin)
Binding affinity to NMDA receptor (unknown origin) at 100 uM patch clamp assay
Assay data:10 Tested
Antagonist activity at NMDA receptor (unknown origin) assessed as NMDA-induced depolarizations
Assay data:4 Tested
Displacement of [3H]MK-801 from NMDA receptor (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 5 Tested
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