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Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Glucocorticoid Eurofins Panlabs panel
GCORTICOID/H Eurofins SafetyScreen44 (BI)
Binding affinity towards human NR3C1 in an in vitro cell free assay measured by filtration, radioactivity method
Assay data:83 Active, 2 Activity ≤ 1 nM, 58 Activity ≤ 1 µM, 1095 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human NR3C1 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:10 Active, 3 Activity ≤ 1 µM, 160 Tested
Agonist activity at human NR3C1 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:6 Active, 3 Activity ≤ 1 µM, 165 Tested
Inhibition of HIS-tagged recombinant human GR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spectrophotometry based DTNB-coupled assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]dexamethasone from human glucocorticoid receptor by scintillation based radioligand binding assay
Antagonist activity at glucocorticoid receptor (unknown origin) transfected in human HeLa cells assessed as inhibition of dexamethasone-induced transactivation of receptor at 10 uM incubated for 18 hrs by firefly luciferase assay
Assay data:58 Tested
Agonist activity at glucocorticoid receptor (unknown origin) transfected in human HeLa cells assessed as transactivation of receptor at 10 uM incubated for 18 hrs by firefly luciferase assay
Assay data:63 Tested
Antagonist activity at glucocorticoid receptor (unknown origin) transfected in human HeLa cells assessed as inhibition of dexamethasone-induced transactivation of receptor incubated for 18 hrs by firefly luciferase assay
Assay data:1 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at glucocorticoid receptor (unknown origin) transfected in human HeLa cells assessed as transactivation of receptor incubated for 18 hrs by firefly luciferase assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Modulation of glucocorticoid receptor (unknown origin) transfected in human HeLa cells assessed as transrepression by measuring inhibition of PMA-induced AP-1 signalling incubated for 18 hrs by dual-luciferase reporter based assay
Assay data:48 Active, 10 Activity ≤ 1 µM, 64 Tested
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