BioAssay by Target (List) for Gene (Select 2912) - PubChem BioAssay - NCBI

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Select item 5493671.

Negative allosteric modulator activity at human mGluR2 expressed in HEK cells assessed as decreasing glutamate Emax at 40 uM by Ca2+ functional assay

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:3 Active, 3 Tested

AID:: 549367

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4789082.

Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calcium flux by FLIPR assay relative to glutamate

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:2 Tested

AID:: 478908

Summary PubMed Citation Related BioAssays by Target

Select item 4789093.

Agonist activity at human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calcium flux by LIPR assay

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:1 Active, 2 Tested

AID:: 478909

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4790604.

Inhibition of mGluR2 expressed in CHO cells at 10 uM

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:17 Tested

AID:: 479060

Summary PubMed Citation Related BioAssays by Target

Select item 4930175.

Wombat Data for BeliefDocking

Source:: Abbott Labs

Assay data:3482 Active, 6170 Tested

AID:: 493017

Summary Compounds, Active PubMed Citation

Select item 4938656.

Inhibition of mGlu2 receptor at 10 uM

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:4 Tested

AID:: 493865

Summary PubMed Citation Related BioAssays by Target

Select item 5139427.

Agonist activity at mGlu2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP level

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:2 Activity ≤ 1 µM, 2 Tested

AID:: 513942

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 5139438.

Antagonist activity at mGlu2 receptor expressed in CHO cells assessed as increase of cAMP level

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:1 Tested

AID:: 513943

Summary PubMed Citation Related BioAssays by Target

Select item 5386839.

Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 mins

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:5 Tested

AID:: 538683

Summary PubMed Citation Related BioAssays by Target

Select item 54840010.

Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 548400

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 54936111.

Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assay

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:4 Active, 3 Activity ≤ 1 µM, 5 Tested

AID:: 549361

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 54936212.

Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested

AID:: 549362

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 54936313.

Negative allosteric modulator activity at human mGluR3 expressed in HEK cells assessed as induction of right shifting of glutamate EC50 at 40 uM by Ca2+ functional assay

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:3 Active, 3 Tested

AID:: 549363

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 54936414.

Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration upto 100 uM by Ca2+ functional assay

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:1 Tested

AID:: 549364

Summary PubMed Citation Related BioAssays by Target

Select item 47890715.

Agonist activity at human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calcium flux by FLIPR assay relative to glutamate

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:2 Tested

AID:: 478907

Summary PubMed Citation Related BioAssays by Target

Select item 56955216.

Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:24 Active, 13 Activity ≤ 1 µM, 28 Tested

AID:: 569552

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 56955317.

Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay relative to glutamate

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:26 Tested

AID:: 569553

Summary PubMed Citation Related BioAssays by Target

Select item 56955518.

Agonist activity at human mGluR2 expressed in HEK293 cells assessed as induction of calcium release by FLIPR assay

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:1 Active, 1 Tested

AID:: 569555

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 56963119.

Binding affinity to mGluR2 receptor

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:1 Tested

AID:: 569631

Summary PubMed Citation Related BioAssays by Target

Select item 57002620.

Antagonist activity at mGlu2 receptor

Source:: ChEMBL

Protein Target:: Metabotropic glutamate receptor 2

Assay data:1 Tested

AID:: 570026

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (187)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (10)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (154)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (254)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (10)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (403)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (14)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (400)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (15)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 2912) (417)
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Gene Links for GEO Profiles (Select 95308313) (1)
Gene
TSPAN9 tetraspanin 9 [Homo sapiens]
TSPAN9 tetraspanin 9 [Homo sapiens]
Gene ID:10867

Gene
GRHL3-depleted epidermal keratinocyte response to the induction of differentiati...
GRHL3-depleted epidermal keratinocyte response to the induction of differentiation in vitro
Accession: GDS5453

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