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Positive allosteric modulation of mGluR7 (unknown origin) assessed as change in forskolin-induced cAMP production by measuring fold change in EC50 shift preincubated with compound for 15 mins in the presence of LY341495 followed by forskolin stimulation and measured after 5 hrs by luminescence based steady glo assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of mGluR7 (unknown origin) assessed as change in forskolin-induced cAMP production by measuring reduction in maximum response preincubated with compound for 15 mins in the presence of LY341495 followed by forskolin stimulation and measured after 5 hrs by luminescence based steady glo assay
Allosteric agonist activity at mGluR7 (unknown origin) assessed as reduction in forskolin-induced cAMP production by measuring fold change in EC50 preincubated for 15 mins in the presence of LY341495 followed by forskolin stimulation and measured after 5 hrs by luminescence based steady glo assay
Assay data:2 Tested
Competitive binding affinity to mGluR7 (unknown origin) assessed as rightward shift in forskolin-induced cAMP production level by measuring fold change preincubated for 15 mins in the presence of LY341495 followed by forskolin stimulation and measured after 5 hrs by luminescence based steady glo assay
Antagonist activity at mGluR7 (unknown origin) assessed as inhibition of L-AP4 stimulated decrease in forskolin induced cAMP response by CRE-Luc assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human mGluR7b expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Desensitization at human mGluR7 expressed in CHO cells assessed as reduction in tool agonist response at EC80 concentration preincubated for 1 hrs followed by compound replacement with assay buffer and measured 1 hrs after tool agonist addition by CellKey impedance assay relative to control
Desensitization at human mGluR7 expressed in CHO cells assessed as reduction in tool agonist response at 10 uM preincubated for 1 hrs followed by compound replacement with assay buffer and measured 1 hrs after tool agonist addition by CellKey impedance assay relative to control
Agonist activity at human mGluR7 expressed in CHO cells assessed as change in extracellular impedance incubated for 40 mins by CellKey impedance assay
Assay data:3 Active, 3 Tested
Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP production by measuring maximum efficacy preincubated for 15 mins followed by forskolin stimulation and measured after 5 hrs by luminescence based Steady glo assay relative to control
Assay data:8 Tested
Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP production preincubated for 15 mins followed by forskolin stimulation and measured after 5 hrs by luminescence based Steady glo assay
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
Positive allosteric modulation of mGluR7 (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay relative to control
Assay data:22 Tested
Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay
Assay data:15 Active, 4 Activity ≤ 1 µM, 16 Tested
In Vitro Pharmacology from US Patent US11414395: "Heterocyclic compounds as modulators of mGluR7"
Assay data:120 Active, 120 Activity ≤ 1 µM, 136 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PRESTO-Tango GPCRome screening (GRM7)
SummaryRelated BioAssays by Target
Binding affinity to mGlu7 (unknown origin)
Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assay relative to L-AP4
Assay data:11 Tested
Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 12 Tested
Positive allosteric modulation of human mGlu7 receptor
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