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Inhibition of rat lung sGC
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
SummaryPubMed Citation
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Activation of human soluble guanylate cyclase assessed as production of cGMP in presence of nitric oxide donor, SIN-1 by FP assay
Assay data:10 Active, 9 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of human soluble guanylate cyclase assessed as production of cGMP in presence of nitric oxide donor, SIN-1 by LC-MS enzyme assay
Assay data:16 Active, 11 Activity ≤ 1 µM, 16 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Inhibition of stimulated guanylate cyclase at 1 uM
Assay data:1 Tested
Activation of soluble guanylate cyclase (unknown origin) assessed as apparent initial rate of oxidation of oxyhemoglobin in presence of cysteine
Assay data:8 Tested
SummaryRelated BioAssays by Target
Effect on cGMP production in porcine iris-ciliary body at 100 uM
Effect on cGMP production in porcine iris-ciliary body at 10 uM
Effect on YC-1 mediated activation of sGC in presence of carbon monoxide
Ratio of activation of sGC by compound over that of control, in absence of carbon monooxide (basal activity 33+/-3 nmol/min/mg)
Assay data:5 Tested
Ratio of activation of sGC by compound over that of control, in presence of carbon monooxide (basal activity 33+/-3 nmol/min/mg in absence of CO)
sGC activation was determined in the presence of [alpha-32P]GTP at a concentration of 82 uM
Assay data:9 Tested
IGC activation was determined in the presence of [alpha-32P]GTP at a concentration of 82 uM
The cGMP produced by compound was expressed as a ratio between the percentage of the DEA/NO response for the compound
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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