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CHO Cellular Assay from US Patent US10550102: "Indane and indoline derivatives and the use thereof as soluble guanylate cyclase activators"
Assay data:159 Active, 92 Activity ≤ 1 nM, 159 Activity ≤ 1 µM, 159 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding Assay from US Patent US10428076: "Soluble guanylate cyclase stimulators"
Assay data:231 Active, 214 Activity ≤ 1 nM, 231 Activity ≤ 1 µM, 231 Tested
Activation Assay from US Patent US9447090: "Imidazopyridine compounds"
Assay data:25 Active, 34 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Homogeneous Time Resolved Fluorescence Assay from US Patent US9353090: "Heterocyclic carboxylic acids as activators of soluble guanylate cyclase"
Assay data:323 Active, 6 Activity ≤ 1 nM, 323 Activity ≤ 1 µM, 323 Tested
Activation Assay from US Patent US9278968: "Imidazopyridine compounds"
Assay data:73 Active, 6 Activity ≤ 1 µM, 106 Tested
Activation of full length human sGC alpha1/beta1 subunit containing heme in ferrous state expressed in Sf9 insect cells using cGMP as substrate incubated for 10 mins by [32P]GTP assay
Assay data:3 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of full length human sGC alpha1/beta1 subunit containing heme in ferric state expressed in Sf9 insect cells using cGMP as substrate incubated for 15 mins at 100 uM incubated for 10 mins by [32P]GTP assay relative to control
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of full length human sGC alpha1/beta1 subunit containing heme in ferric state expressed in Sf9 insect cells using cGMP as substrate incubated for 15 mins by [32P]GTP assay
Assay data:27 Tested
Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO and Tween-20
Assay data:1 Tested
Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO and ODQ
Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO
Assay data:1 Active, 1 Tested
Activation of sGC (unknown origin) in presence of DETA-NO by Glosensor cGMP assay
Assay data:27 Active, 22 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of human sGC subunit alpha1/beta1 expressed in CHO cells assessed as cGMP production in presence of ODQ by CASA assay
Activation of human sGC subunit alpha1/beta1 expressed in CHO cells assessed as cGMP production by CASA assay
Assay data:23 Active, 15 Activity ≤ 1 µM, 31 Tested
Inhibition of soluble guanylate cyclase (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Activation of sGC (unknown origin) assessed as cGMP formation using GTP as substrate by Catch-point cGMP assay relative to DMSO
Assay data:24 Tested
SummaryRelated BioAssays by Target
Activation of SGC in HEK293 cells assessed as cGMP production at 30 uM after 20 mins by LC-MS/MS analysis in presence of NO-donor DETA-NONOate
Assay data:13 Tested
Activation of SGC in HEK293 cells assessed as cGMP production after 20 mins by LC-MS/MS analysis in presence of NO-donor DETA-NONOate
Assay data:19 Active, 17 Activity ≤ 1 µM, 33 Tested
Binding affinity to full length human recombinant sGC by surface plasmon resonance analysis
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