BioAssay by Target (List) for Gene (Select 3055) - PubChem BioAssay - NCBI

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Select item 19564661.

Inhibition of GST-tagged human recombinant HCK expressed in insect cells at 200 nM by Z'-lyte assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Tested

AID:: 1956466

Summary Related BioAssays by Target

Select item 19544812.

Inhibition of HCK (unknown origin) by Z'LYTE assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1954481

Summary Related BioAssays by Target

Select item 19544503.

Inhibition of HCK (unknown origin) incubated for 1 hr in presence of ATP by Z'LYTE assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1954450

Summary Related BioAssays by Target

Select item 19136854.

Selectivity interaction (Z?-LYTE assay) EUB0000638a HCK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Tested

AID:: 1913685

Summary Related BioAssays by Target

Select item 19135725.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000147b HCK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Tested

AID:: 1913572

Summary Related BioAssays by Target

Select item 18953746.

Inhibition of recombinant Hck (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1895374

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18761807.

Inhibition of Nef activated HCK (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Active, 1 Tested

AID:: 1876180

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18727148.

Inhibition of HCK (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1872714

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18357249.

HCK DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Tested

AID:: 1835724

Summary Related BioAssays by Target

Select item 183498810.

Hck(h) activated Kinase panel

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Tested

AID:: 1834988

Summary Related BioAssays by Target

Select item 183498711.

Hck(h) Kinase panel

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Tested

AID:: 1834987

Summary Related BioAssays by Target

Select item 183416012.

Inhibition of HCK (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Tested

AID:: 1834160

Summary PubMed Citation Related BioAssays by Target

Select item 181629113.

Inhibition of human recombinant Hck assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:1 Tested

AID:: 1816291

Summary PubMed Citation Related BioAssays by Target

Select item 180544014.

Protein Kinase Assay from US Patent US10975058: "Imidazolyl kinase inhibitors and uses thereof"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase BTK; ...
Total:: 2

Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested

AID:: 1805440

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180505515.

Inhibition Assay from US Patent US10844077: "Thiazolyl-containing compounds for treating proliferative diseases"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase HCK; ...
Total:: 2

Assay data:20 Active, 8 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 22 Tested

AID:: 1805055

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180504316.

Biological Activity Assay from US Patent US10844038: "1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions"

Source:: BindingDB

Protein Targets:: Mast/stem cell growth factor receptor Kit; ...
Total:: 6

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1805043

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180460217.

Kinase Selectivity Assay from US Patent US10711006: "Selective Bruton's tyrosine kinase inhibitor and use thereof"

Source:: BindingDB

Protein Targets:: Receptor-type tyrosine-protein kinase FLT3; ...
Total:: 7

Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1804602

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180436818.

In Vitro Activity Assay from US Patent US10633348: "Methods to treat lymphoplasmacytic lymphoma"

Source:: BindingDB

Protein Targets:: Hexokinase-4; ...
Total:: 4

Assay data:14 Active, 12 Activity ≤ 1 µM, 16 Tested

AID:: 1804368

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180433519.

In Vitro Activity Assay from US Patent US10597387: "Methods to treat lymphoplasmacytic lymphoma"

Source:: BindingDB

Protein Targets:: Nuclear receptor subfamily 2 group C member 2; ...
Total:: 3

Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1804335

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180410320.

luminescent kinase assay from US Patent US10544104: "Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases"

Source:: BindingDB

Protein Targets:: Proto-oncogene tyrosine-protein kinase Src; ...
Total:: 3

Assay data:129 Active, 6 Activity ≤ 1 nM, 112 Activity ≤ 1 µM, 141 Tested

AID:: 1804103

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

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Target

Proteins (4)
BioAssays with protein sequences specified as targets
RNAi Target, Active (9)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (89)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (18)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (79)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (111)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (297)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (45)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (263)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (76)
BioAssays deposited by other experimentalists

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