Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
ACC1 Enzyme Activity Assay from US Patent US11186587: "Compound as ACC inhibitor and use thereof"
Assay data:31 Active, 8 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
etermination of IC50 of Inhibition of Enzymatic Activity of ACC1 and ACC2 by the Compound of the Present Disclosure from US Patent US11142531: "Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Acetyl-CoA Carboxylase (ACC) Inhibition Assay from US Patent US10995099: "Compounds and their uses as ACC inhibitors"
Assay data:52 Active, 6 Activity ≤ 1 nM, 59 Activity ≤ 1 µM, 59 Tested
ACCase Enzymatic Assay from US Patent US10995070: "Acetyl-CoA carboxylase modulators"
Assay data:12 Active, 5 Activity ≤ 1 µM, 15 Tested
Kinase Assay from US Patent US10759812: "Thienopyrimidine derivative and use thereof in medicine"
Assay data:15 Active, 6 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Human ACC1 Enzyme Assay from US Patent US9278925: "Substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one"
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
ACC1 Enzyme Assay B1 from US Patent US9212140: "(5s,8s)-3-(4′-chlor-3′-fluor-4-methlybiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5] dec-3-en-2-one (compound A) for treatment"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
ACC1 Enzyme Assay A1 from US Patent US9212140: "(5s,8s)-3-(4′-chlor-3′-fluor-4-methlybiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5] dec-3-en-2-one (compound A) for treatment"
Inhibition Assay from US Patent US8993586: "N1/N2-lactam acetyl-CoA carboxylase inhibitors"
Assay data:124 Active, 118 Activity ≤ 1 µM, 124 Tested
Luminometric Assay from US Patent US8470841: "Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof"
Assay data:33 Active, 24 Activity ≤ 1 µM, 33 Tested
Inhibition of ACC1 in human HepG2 cells assessed as lipid content using 13C-labelled acetate as substrate incubated for 1 hr followed by substrate addition and measured after 24 hrs by QTOF mass spectrometer
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ACC1 in human HepG2 cells assessed as reduction in intracellular triglyceride level at 10 uM measured after 48 hrs by GPO-PAP method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ACC1 in human HepG2 cells assessed as reduction in intracellular malonyl-CoA level at 10 uM measured after 48 hrs by ELISA relative to control
Inhibition of ACC1 in human HepG2 cells assessed as reduction in intracellular triglyceride level measured after 48 hrs by GPO-PAP method
Inhibition of ACC1 in human HepG2 cells assessed as reduction in intracellular malonyl-CoA level measured after 48 hrs by ELISA
Inhibition of recombinant human C-terminal His-tagged ACC1 (1 to 2383 residues) expressed in baculovirus infected Sf9 insect cells preincubated for 15 mins followed by substrate addition and measured after 60 mins by ADP-glo luminescence assay
Assay data:13 Active, 23 Activity ≤ 1 µM, 23 Tested
Inhibition of recombinant human C-terminal His-tagged ACC1 (1 to 2383 residues) expressed in baculovirus infected Sf9 insect cells at 0.1 uM preincubated for 15 mins followed by substrate addition and measured after 60 mins by ADP-glo luminescence assay relative to control
Assay data:22 Tested
Inhibition of recombinant human C-terminal His-tagged ACC1 (1 to 2383 residues) expressed in baculovirus infected Sf9 insect cells at 5 uM preincubated for 15 mins followed by substrate addition and measured after 60 mins by ADP-glo luminescence assay relative to control
Inhibition of recombinant human N-terminal His6-tagged ACC1 expressed in baculovirus infected Sf9 insect cells at 10 uM using acetyl-CoA as substrate preincubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry relative to control
Assay data:3 Tested
Inhibition of recombinant human N-terminal His6-tagged ACC1 expressed in baculovirus infected Sf9 insect cells using acetyl-CoA as substrate preincubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry
Assay data:15 Active, 14 Activity ≤ 1 µM, 15 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on