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HMG-CoA Reductase Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Induction of HMGCR degradation (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of HMGCR degradation in human HepG2 cells incubated for 3 hrs by densitometric analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of HMGCR degradation in HEK293 cells incubated for 4 hrs by luciferase based assay
Assay data:22 Active, 20 Activity ≤ 1 µM, 27 Tested
Inhibition of HMG CoA reductase (unknown origin)
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HMG-CoA reductase (unknown origin) in presence of cathepsin B
Assay data:3 Active, 3 Tested
Inhibition of HMG-CoA reductase (unknown origin) in neutral aqueous media
Assay data:2 Active, 4 Tested
PROTAC activity at VHL/recombinant HMGCR in human Insig-depletion HepG2 cells assessed as degradation of HMGCR measured at 1 uM after 16 hrs relative to control
PROTAC activity at VHL/recombinant HMGCR in human Insig-depletion HepG2 cells assessed as degradation of HMGCR measured after 16 hrs
PROTAC activity at VHL/recombinant HMGCR in human HepG2 cells assessed as degradation of HMGCR measured at 0.1 uM after 16 hrs relative to control
Inhibition of HMGCR (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
PROTAC activity at VHL/HMGCR in human HepG2 cells assessed as degradation of HMGCR measured at 1 uM after 16 hrs relative to control
Degradation of HMGCR (unknown origin)
Degradation of HMGCR (unknown origin) expressed in CHO-7 cells
Induction of HMGCR-T7 (unknown origin) degradation transfected in CHO-K1 cells assessed as HMGCR ubiquitination preincubated in sterol-depleted medium for 16 hrs followed by compound addition and measured after 4 hrs in presence of MG-132 by immuno-precipicitation analysis
Protac activity at VHL/HMGCR in Insig-silenced human HepG2 cells
HMG-CoA Reductase Eurofins-Panlabs enzyme assay
Reductase Activity Assay from US Patent US9353061: "3,5,N-trihydroxy-alkanamide and derivatives: method for making same and use thereof"
Assay data:6 Active, 6 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Reductase Activity Assay from US Patent US9115116: "Dual action inhibitors against histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme a reductase"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Reductase Assay from US Patent US9102656: "Use of rosuvastatin lactols as medicaments"
Assay data:12 Active, 3 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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